Impact of Glucose Loading on Variations in CD4+ and CD8+ T Cells in Japanese Participants with or without Type 2 Diabetes

Miya, Aika; Nakamura, Akinobu; Miyoshi, Hideaki et al.

Frontiers in Endocrinology, 2018, 9, 81

Permalink : https://hdl.handle.net/2115/70876

このアイテムのアクセス数:917件（2026-11-06 09:57 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
table_15 doc 27.0 KB 197 Table s15
table_14 doc 30.5 KB 203 Table s14
table_13 doc 36.0 KB 220 Table s13
table_12 doc 30.0 KB 188 Table s12
table_11 doc 36.5 KB 233 Table s11
table_10 doc 30.0 KB 200 Table s10
table_9 doc 34.0 KB 210 Table s9
table_8 doc 29.0 KB 200 Table s8
table_7 doc 29.5 KB 200 Table s7
table_6 doc 36.0 KB 216 Table s6
table_5 doc 30.0 KB 217 Table s5
table_4 doc 30.0 KB 197 Table s4
table_3 doc 30.0 KB 209 Table s3
table_2 doc 30.0 KB 234 Table s2
table_1 doc 34.5 KB 241 Table s1
endo-09-00081 pdf 464 KB 464

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/70876
タイトル
Impact of Glucose Loading on Variations in CD4+ and CD8+ T Cells in Japanese Participants with or without Type 2 Diabetes
著者
Miya, Aika ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Takano, Yoshinari ; Sunagoya, Kana ; Hayasaka, Koji ; Shimizu, Chikara ; Terauchi, Yasuo ; Atsumi, Tatsuya
著者名
Miya, Aika
e-Rad_Researcher
70552420
著者名
Nakamura, Akinobu
e-Rad_Researcher
30360902
著者名
Miyoshi, Hideaki
著者名
Takano, Yoshinari
著者名
Sunagoya, Kana
著者名
Hayasaka, Koji
e-Rad_Researcher
00292029
著者名
Shimizu, Chikara
著者名
Terauchi, Yasuo
e-Rad_Researcher
20301905
著者名
Atsumi, Tatsuya
言語
英語
キーワード
proportion of CD4+ and CD8+ T cells
oral glucose tolerance test
glucose loading
glucose metabolism
lymphocytes
発行日
2018-03-20
出版者
Frontiers Media
収録物名
Frontiers in Endocrinology
巻(号)
9
ページ
81
抄録
Objective: The aim of this study was to examine the fluctuations in CD4+ T cells, CD8+ T cells, and natural CD4+CD25+FoxP3+T-regulatory (Treg) cells following an oral glucose tolerance test (OGTT) in participants with and those without type 2 diabetes (T2DM). Methods: 19 Japanese participants with T2DM (DM group) and 21 participants without diabetes (non-DM group) were recruited and underwent a 75-g OGTT. The cell numbers of leukocytes, lymphocytes, and the T cell compartment, such as CD4+, CD8+, and Treg, were calculated for blood samples obtained after an overnight 12 h fast and during a 75-g OGTT at 60 and 120 min. Results: Before glucose loading, no differences in the cell numbers of leukocytes, lymphocytes, CD4+, CD8+, and Treg were observed between the DM group and the non-DM group. The proportion of CD8+ was significantly reduced, whereas the proportion of CD4+ was significantly increased, after 120 min of glucose loading in both groups. The proportion of Treg was not affected. Furthermore, a significant positive correlation was observed between the AUC0-120 min of CD8+ and the change in the free fatty acid level following the OGTT (ρ = 0.39, P < 0.05), but not that of glucose or insulin. Conclusion: The proportion of CD4+ T cells was increased and that of CD8+ T cells was reduced after glucose loading in both subjects with and without diabetes. These findings suggest that glucose loading dynamically affects the balance of the circulating T lymphocyte subset, regardless of glucose tolerance.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1664-2392
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3389/fendo.2018.00081