open access

https://hdl.handle.net/2115/70897

Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women : Association with small-for-gestational-age neonates

Placental growth factor and SGA

英語

small for gestational age

2017-07

John Wiley & Sons

Journal of Obstetrics and Gynaecology Research

43(7)

1152-1158

Aims: This study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels at mid-gestation with the risk of small for gestational age (SGA) neonates born at gestational week (GW) ≥ 36 in healthy women. Methods: PlGF and sFlt-1 concentrations were determined at GW 24-27 in 183 women with births at GW ≥ 36, but without gestational diabetes mellitus and hypertension. Results: Thirteen (7.1%) SGA neonates were born. Median (range) GW at blood sampling was similar between women with and without SGA (25 [24-25] and 24 [24-27], respectively, P = 0.671). Pre-pregnancy body mass index (BMI) and PlGF levels were significantly lower in women with than without SGA, while sFlt-1 levels and sFlt-1:PlGF ratio (sFlt-1/PlGF) did not differ significantly between the two groups. PlGF and sFlt-1/PlGF, but not BMI or sFlt-1, showed significant correlations with birthweight z-score; the correlation was positive for PlGF and negative for sFlt-1/PlGF. Women with PlGF level < 10th percentile and those with sFlt-1/PlGF level > 90th percentile showed significantly increased risk of SGA compared to those with respective counterpart characteristics; relative risk was 3.8 (95% CI, 1.3 - 11.3; 21% [4/19] vs. 5.5% [9/164]) for PlGF and 7.9 (3.0 - 20.8, 33.3% [6/18] vs. 4.2% [7/165]) for sFlt-1/PlGF. Conclusions: Maternal PlGF and sFlt-1/PlGF determined during GW 24-27 were associated with the risk of SGA born at GW ≥ 36, even in women with uncomplicated pregnancies.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Itsuko Furuta, Takeshi Umazume, Takashi Kojima, Kentaro Chiba, Kinuko Nakagawa, Ami Hosokawa, Satoshi Ishikawa, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami, Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women: Association with small-for-gestational-age neonates, The Journal of Obstetrics and Gynaecology Research, Volume43, Issue7, 2017, pp.1152-1158, which has been published in final form at https://doi.org/10.1111/jog.13340. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

1341-8076