Assessment of impulsivity in adolescent mice : A new training procedure for a 3-choice serial reaction time task

Sasamori, Hitomi; Ohmura, Yu; Kubo, Takuya; Yoshida, Takayuki; Yoshioka, Mitsuhiro

Assessment of impulsivity in adolescent mice : A new training procedure for a 3-choice serial reaction time task

Sasamori, Hitomi; Ohmura, Yu; Kubo, Takuya et al.

Behavioural brain research, 2018, 343, 61-70

Permalink : https://hdl.handle.net/2115/70904

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SupplementaryMaterials-program(hierarchical_Bayesian_model)_201802001410750800	txt	0.78 KB	303	Appendix A. Supplementary data
SupplementaryMaterials-program(target_phase)_201802001410750801	txt	13.6 KB	323	Appendix A. Supplementary data
SupplementaryMaterials-program(training_phase_in_novel_procedure)_201802001410750802	txt	14.1 KB	339	Appendix A. Supplementary data
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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/70904
タイトル	Assessment of impulsivity in adolescent mice : A new training procedure for a 3-choice serial reaction time task
著者	Sasamori, Hitomi ; Ohmura, Yu ; Kubo, Takuya ; Yoshida, Takayuki ; Yoshioka, Mitsuhiro
著者名 Sasamori, Hitomi
e-Rad_Researcher 80597659 著者名 Ohmura, Yu
e-Rad_Researcher 80344498 著者名 Kubo, Takuya
e-Rad_Researcher 60374229 著者名 Yoshida, Takayuki
e-Rad_Researcher 40182729 著者名 Yoshioka, Mitsuhiro
言語	英語
キーワード	Development
	C57BL/6N
	Behavioral inhibition
	Executive function
発行日	2018-05-02
出版者	Elsevier
収録物名	Behavioural brain research
巻(号)	343
ページ	61-70
抄録	Immaturity in impulse control among adolescents could result in substance abuse, criminal involvement, and suicide. The brains of adolescents and adults are anatomically, neurophysiologically, and pharmacologically different. Therefore, preclinical models of adolescent impulsivity are required to screen drugs for adolescents and elucidate the neural mechanisms underlying age-related differences in impulsivity. The conventional 3- or 5-choice serial reaction time task, which is a widely used task to assess impulsivity in adult rodents, cannot be used for young mice because of two technical problems: impaired growth caused by food restriction and the very long training duration. To overcome these problems, we altered the conventional training process, optimizing the degree of food restriction for young animals and shortening the training duration. We found that almost all basal performance levels were similar between the novel and conventional procedures. We also confirmed the pharmacological validity of our results: the 5-hydroxytryptamine 2C (5-HT2C) receptor agonist Ro60-0175 (0.6 mg/kg, subcutaneous) reduced the occurrence of premature responses, whereas the 5-HT2C receptor antagonist SB242084 (0.5 mg/kg intraperitoneal) increased their occurrence, consistent with results of previous studies using conventional procedures. Furthermore, we detected age-related differences in impulsivity using the novel procedure: adolescent mice were found to be more impulsive than adult mice, congruent with the results of human studies. Thus, the new procedure enables the assessment of impulsivity in adolescent mice and facilitates a better understanding of the neurophysiological/pharmacological properties of adolescents.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	0166-4328
関連情報	PMID 29355672
関連情報 (references)	HDL https://hdl.handle.net/2115/70905
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.bbr.2018.01.014