Nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O : observation of unexpected regioselectivity

Doi, Ryohei; Abdullah, Iman; Taniguchi, Takahisa et al.

Chemical communications, 2017, 53(55), 7720-7723

Permalink : https://hdl.handle.net/2115/70974

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アクセス権	open access
URI	https://hdl.handle.net/2115/70974
タイトル	Nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O : observation of unexpected regioselectivity
著者	Doi, Ryohei ; Abdullah, Iman ; Taniguchi, Takahisa ; Saito, Nozomi ; Sato, Yoshihiro
著者名 Doi, Ryohei
著者名 Abdullah, Iman
著者名 Taniguchi, Takahisa
著者名 Saito, Nozomi
e-Rad_Researcher 90226019 著者名 Sato, Yoshihiro
言語	英語
発行日	2017-07-14
出版者	Royal Society of Chemistry
収録物名	Chemical communications
巻(号)	53(55)
ページ	7720-7723
抄録	We describe the nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O to afford a variety of alpha-amino-alpha, beta-unsaturated esters with high regioselectivities. The selective alpha-carboxylation of ynamides with this catalytic protocol is unexpected in view of the electronic bias of ynamides and is in sharp contrast to our previous study in which a stoichiometric amount of Ni(0) was used to form a beta-carboxylated product exclusively. We revealed that this unexpected C-C bond formation was induced by the combination of Zn and MgBr2.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1359-7345
関連情報	PMID 28569298
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1039/c7cc03127k