Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases

Nakano, Fumihito; Sakushima, Ken; Umeki, Reona; Yabe, Ichiro; Endoh, Akira; Sasaki, Hidenao

Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases

Nakano, Fumihito; Sakushima, Ken; Umeki, Reona et al.

Journal of the neurological sciences, 2017, 378, 45-48

Permalink : https://hdl.handle.net/2115/70975

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アクセス権	open access
URI	https://hdl.handle.net/2115/70975
タイトル	Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases
その他のタイトル	Effects of age and glucose on lactate in CSF
著者	Nakano, Fumihito ; Sakushima, Ken ; Umeki, Reona ; Yabe, Ichiro ; Endoh, Akira ; Sasaki, Hidenao
著者名 Nakano, Fumihito
著者名 Sakushima, Ken
著者名 Umeki, Reona
e-Rad_Researcher 60372273 著者名 Yabe, Ichiro
著者名 Endoh, Akira
e-Rad_Researcher 80281806 著者名 Sasaki, Hidenao
言語	英語
キーワード	Cerebrospinal fluid
	Lactate
	Glucose
	Age
	Neurodegenerative disease
発行日	2017-07-15
出版者	Elsevier
収録物名	Journal of the neurological sciences
巻(号)	378
ページ	45-48
抄録	Despite recent studies examining the association between neurodegenerative diseases and mitochondrial dysfunction, there are not sufficient data on factors that influence cerebrospinal fluid (CSF) lactate levels. Thus, we investigated factors that affect CSF lactate levels in neurodegenerative diseases. We extracted laboratory findings, including CSF lactate, glucose, and protein levels, and demographic and background information, including age and gender, from the electronic medical records of patients with neurodegenerative diseases in order to explore factors that have an impact CSF lactate levels. These patients had been admitted to our department and underwent a CSF examination between April 2007 and March 2015. Data from 83 patients (average age 64.5 years; 45 males and 38 females) were analyzed. The patients' diagnoses included amyotrophic lateral sclerosis, multiple system atrophy, spinocerebellar degeneration, corticobasal syndrome, Parkinson's disease, and Huntington's disease. CSF lactate levels were higher in patients with a neurodegenerative disease who were aged 65 years and older relative to those who were aged under 65 years (p < 0.05), and CSF lactate and glucose levels showed a moderate positive correlation (r = 0.487). Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender, age, CSF protein levels, and CSF glucose levels. When investigating CSF lactate levels in neurodegenerative diseases, it is necessary to consider patients' age and CSF glucose levels.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0022-510X
関連情報	PMID 28566176
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jns.2017.04.033