Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

Sasaki, Ayana; Nagatake, Takahiro; Egami, Riku; Gu, Guoqiang; Takigawa, Ichigaku; Ikeda, Wataru; Nakatani, Tomoya; Kunisawa, Jun; Fujita, Yasuyuki

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

Sasaki, Ayana; Nagatake, Takahiro; Egami, Riku et al.

Cell Reports, 2018, 23(4), 974-982

Permalink : https://hdl.handle.net/2115/70992

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/70992
タイトル	Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues
著者	Sasaki, Ayana ; Nagatake, Takahiro ; Egami, Riku ; Gu, Guoqiang ; Takigawa, Ichigaku ; Ikeda, Wataru ; Nakatani, Tomoya ; Kunisawa, Jun ; Fujita, Yasuyuki
著者名 Sasaki, Ayana
著者名 Nagatake, Takahiro
著者名 Egami, Riku
著者名 Gu, Guoqiang
e-Rad_Researcher 10374597 著者名 Takigawa, Ichigaku
著者名 Ikeda, Wataru
著者名 Nakatani, Tomoya
著者名 Kunisawa, Jun
e-Rad_Researcher 50580974 著者名 Fujita, Yasuyuki
言語	英語
発行日	2018-04-24
出版者	Cell Press
収録物名	Cell Reports
巻(号)	23(4)
ページ	974-982
抄録	Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelial tissues via cell competition with the surrounding normal epithelial cells. This cancer preventive phenomenon is termed epithelial defense against cancer (EDAC). However, it remains largely unknown whether and how EDAC is diminished during carcino-genesis. In this study, using a cell competition mouse model, we show that high-fat diet (HFD) feeding substantially attenuates the frequency of apical elimination of RasV12-transformed cells from intestinal and pancreatic epithelia. This process involves both lipid metabolism and chronic inflammation. Furthermore, aspirin treatment significantly facilitates eradication of transformed cells from the epithelial tissues in HFD-fed mice. Thus, our work demonstrates that obesity can profoundly influence competitive interaction between normal and transformed cells, providing insights into cell competition and cancer preventive medicine.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	2211-1247
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.celrep.2018.03.104