Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy

Miyazawa, Hajime; Yanagi, Teruki; Yamaguchi, Yasuyuki; Imafuku, Keisuke; Kitamura, Shinya; Hata, Hiroo; Uehara, Jiro; Ichikawa, Nobuki; Ohno, Yosuke; Yoshida, Tadashi; Homma, Shigenori; Kawamura, Hideki; Taketomi, Akinobu; Shimizu, Hiroshi

Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy

Miyazawa, Hajime; Yanagi, Teruki; Yamaguchi, Yasuyuki et al.

Journal of dermatology, 2017, 44(8), 959-962

Permalink : https://hdl.handle.net/2115/71133

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アクセス権	open access
URI	https://hdl.handle.net/2115/71133
タイトル	Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy
その他のタイトル	Intestinal metastasis in melanoma
著者	Miyazawa, Hajime ; Yanagi, Teruki ; Yamaguchi, Yasuyuki ; Imafuku, Keisuke ; Kitamura, Shinya ; Hata, Hiroo ; Uehara, Jiro ; Ichikawa, Nobuki ; Ohno, Yosuke ; Yoshida, Tadashi ; Homma, Shigenori ; Kawamura, Hideki ; Taketomi, Akinobu ; Shimizu, Hiroshi
著者名 Miyazawa, Hajime
e-Rad_Researcher 50755973 著者名 Yanagi, Teruki
著者名 Yamaguchi, Yasuyuki
著者名 Imafuku, Keisuke
著者名 Kitamura, Shinya
e-Rad_Researcher 90399915 著者名 Hata, Hiroo
著者名 Uehara, Jiro
e-Rad_Researcher 50779890 著者名 Ichikawa, Nobuki
著者名 Ohno, Yosuke
e-Rad_Researcher 70772333 著者名 Yoshida, Tadashi
e-Rad_Researcher 30533674 著者名 Homma, Shigenori
e-Rad_Researcher 70645960 著者名 Kawamura, Hideki
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
言語	英語
キーワード	fecal occult blood test
	intestinal metastasis
	malignant melanoma
	nivolumab
	weight loss
発行日	2017-08
出版者	John Wiley & Sons
収録物名	Journal of dermatology
巻(号)	44(8)
ページ	959-962
抄録	We report two cases of melanomas in patients who developed intestinal metastasis despite other metastatic sites responding to nivolumab and despite the patients having favorable findings such as vitiligo and normal lactate dehydrogenase. The first case is an 85-year-old man who had been administrated nivolumab for lung/cutaneous metastases. After 22 courses of nivolumab therapy, fever and anorexia had appeared and his bodyweight had decreased. An intussusception on the ileocecal valve was revealed by computed tomography, and emergency surgery revealed metastatic lesions on the colon. The second case is an 87-year-old woman treated with nivolumab for lymph node metastases. After 10 courses, laboratory tests had revealed anemia and positive fecal occult blood. Her bodyweight had decreased. Capsule endoscopy showed scattered tumors and clots, indicating metastases of melanoma. The frequency of symptomatic intestinal metastasis of melanoma is very low. Further, intestinal metastasis of melanoma is difficult to detect through routine examinations. Our cases suggest that fecal occult blood test and decreased bodyweight are indications of intestinal metastases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Miyazawa, H., Yanagi, T., Yamaguchi, Y., Imafuku, K., Kitamura, S., Hata, H., Uehara, J., Ichikawa, N., Ohno, Y., Yoshida, T., Homma, S., Kawamura, H., Taketomi, A. and Shimizu, H. (2017), Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy. J Dermatol, 44: 959-962., which has been published in final form at https://doi.org/10.1111/1346-8138.13825. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	0385-2407
関連情報	PMID 28295515
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/1346-8138.13825