The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus

Matsuno, Keita; Kajihara, Masahiro; Nakao, Ryo; Nao, Naganori; Mori-Kajihara, Akina; Muramatsu, Mieko; Qiu, Yongjin; Torii, Shiho; Igarashi, Manabu; Kasajima, Nodoka; Mizuma, Keita; Yoshii, Kentaro; Sawa, Hirofumi; Sugimoto, Chihiro; Takada, Ayato; Ebihara, Hideki

The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus

Matsuno, Keita; Kajihara, Masahiro; Nakao, Ryo et al.

mSphere, 2018, 3(3), e00239-18

Permalink : https://hdl.handle.net/2115/71358

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アクセス権	open access
URI	https://hdl.handle.net/2115/71358
タイトル	The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
著者	Matsuno, Keita ; Kajihara, Masahiro ; Nakao, Ryo ; Nao, Naganori ; Mori-Kajihara, Akina ; Muramatsu, Mieko ; Qiu, Yongjin ; Torii, Shiho ; Igarashi, Manabu ; Kasajima, Nodoka ; Mizuma, Keita ; Yoshii, Kentaro ; Sawa, Hirofumi ; Sugimoto, Chihiro ; Takada, Ayato ; Ebihara, Hideki
e-Rad_Researcher 40753306 著者名 Matsuno, Keita
著者名 Kajihara, Masahiro
e-Rad_Researcher 50633955 著者名 Nakao, Ryo
著者名 Nao, Naganori
著者名 Mori-Kajihara, Akina
著者名 Muramatsu, Mieko
著者名 Qiu, Yongjin
著者名 Torii, Shiho
e-Rad_Researcher 10374240 著者名 Igarashi, Manabu
著者名 Kasajima, Nodoka
著者名 Mizuma, Keita
e-Rad_Researcher 50421988 著者名 Yoshii, Kentaro
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 90231373 著者名 Sugimoto, Chihiro
e-Rad_Researcher 10292062 著者名 Takada, Ayato
著者名 Ebihara, Hideki
言語	英語
キーワード	ancestral state
	evolution
	phylogenetic analysis
	tick-borne phlebovirus
発行日	2018-06-13
出版者	American Society for Microbiology
収録物名	mSphere
巻(号)	3(3)
ページ	e00239-18
抄録	The recent emergence of novel tick-borne RNA viruses has complicated the epidemiological landscape of tick-borne infectious diseases, posing a significant challenge to public health systems that seek to counteract tick-borne diseases. The identification of two novel tick-borne phleboviruses (TBPVs), severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV), as causative agents of severe illness in humans has accelerated the investigation and discoveries of novel TBPVs. In the present study, we isolated a novel TBPV designated Mukawa virus (MKWV) from host-questing Ixodes persulcatus females captured in Japan. Genetic characterization revealed that MKWV is a member of the genus Phlebovirus in the family Phenuiviridae. Interestingly, MKWV is genetically distinct from other known TBPVs and shares a most recent common ancestor with mosquito/sandfly-borne (insect-borne) phleboviruses. Despite its genetic similarity to insect-borne phleboviruses, the molecular footprints of its viral proteins and its biological characteristics define MKWV as a tick-borne virus that can be transmitted to mammals. A phylogenetic ancestral-state reconstruction for arthropod vectors of phleboviruses including MKWV based on viral L segment sequences indicated that ticks likely harbored ancestral phleboviruses that evolved into both the tick-borne and MKWV/insect-borne phlebovirus lineages. Overall, our findings suggest that most of the phlebovirus evolution has occurred in hard ticks to generate divergent viruses, which may provide a seminal foundation for understanding the mechanisms underlying the evolution and emergence of pathogenic phleboviruses, such as Rift Valley fever virus and SFTSV/HRTV.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2379-5042
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1128/mSphere.00239-18