Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

Kunimatsu, Jun; Suzuki, Tomoki W; Ohmae, Shogo; Tanaka, Masaki

Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

Kunimatsu, Jun; Suzuki, Tomoki W; Ohmae, Shogo et al.

Elife, 2018, 7, e35676

Permalink : https://hdl.handle.net/2115/71497

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elife-35676-fig3-figsupp2-v2	jpg	276 KB	59	Figure 3, figure supplement 2
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elife-35676-fig1-data1-v2	zip	26.2 KB	88	Figure 1, source data 1: Data for Figure 1B
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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/71497
タイトル	Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing
著者	Kunimatsu, Jun ; Suzuki, Tomoki W ; Ohmae, Shogo ; Tanaka, Masaki
e-Rad_Researcher 50632395 著者名 Kunimatsu, Jun
著者名 Suzuki, Tomoki W
著者名 Ohmae, Shogo
e-Rad_Researcher 90301887 著者名 Tanaka, Masaki
言語	英語
発行日	2018-07-02
出版者	eLife Sciences Publications
収録物名	Elife
巻(号)	7
ページ	e35676
抄録	The ability to flexibly adjust movement timing is important for everyday life. Although the basal ganglia and cerebellum have been implicated in monitoring of supra-and sub-second intervals, respectively, the underlying neuronal mechanism remains unclear. Here, we show that in monkeys trained to generate a self-initiated saccade at instructed timing following a visual cue, neurons in the caudate nucleus kept track of passage of time throughout the delay period, while those in the cerebellar dentate nucleus were recruited only during the last part of the delay period. Conversely, neuronal correlates of trial-by-trial variation of self-timing emerged earlier in the cerebellum than the striatum. Local inactivation of respective recording sites confirmed the difference in their relative contributions to supra-and sub-second intervals. These results suggest that the basal ganglia may measure elapsed time relative to the intended interval, while the cerebellum might be responsible for the fine adjustment of self-timing.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons CC0 1.0 Universal
PISSN	2050-084X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.7554/eLife.35676