Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction : 11C-hydroxyephedrine PET study

Aikawa, Tadao; Naya, Masanao; Obara, Masahiko; Oyama-Manabe, Noriko; Manabe, Osamu; Magota, Keiichi; Ito, Yoichi M.; Katoh, Chietsugu; Tamaki, Nagara

Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction : 11C-hydroxyephedrine PET study

Aikawa, Tadao; Naya, Masanao; Obara, Masahiko et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2017, 44(11), 1897-1905

Permalink : https://hdl.handle.net/2115/71560

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アクセス権	open access
URI	https://hdl.handle.net/2115/71560
タイトル	Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction : 11C-hydroxyephedrine PET study
著者	Aikawa, Tadao ; Naya, Masanao ; Obara, Masahiko ; Oyama-Manabe, Noriko ; Manabe, Osamu ; Magota, Keiichi ; Ito, Yoichi M. ; Katoh, Chietsugu ; Tamaki, Nagara
e-Rad_Researcher 20795059 著者名 Aikawa, Tadao
e-Rad_Researcher 20455637 著者名 Naya, Masanao
著者名 Obara, Masahiko
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 40443957 著者名 Manabe, Osamu
e-Rad_Researcher 20636419 著者名 Magota, Keiichi
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 10292012 著者名 Katoh, Chietsugu
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	heart failure with preserved ejection fraction
	11C-hydroxyephedrine
	regional sympathetic denervation
	contractile dysfunction
	myocardial fibrosis
発行日	2017-10
出版者	Springer
収録物名	European Journal of Nuclear Medicine and Molecular Imaging
巻(号)	44(11)
ページ	1897-1905
抄録	Purpose: This investigation aimed to identify significant predictors of regional sympathetic denervation quantified by 11C-hydroxyephedrine (HED) positron emission tomography (PET) in patients with heart failure with preserved left ventricular ejection fraction (HFpEF). Methods: Thirty-four patients (63 ± 15 years, 23 male) with HFpEF (left ventricular ejection fraction ≥ 40%) and 11 age-matched volunteers without heart failure were included. Cardiac magnetic resonance imaging was performed to measure left ventricular size, function, and the extent of myocardial late gadolinium enhancement (LGE). 11C-HED PET was performed to quantify myocardial sympathetic innervation expressed as 11C-HED retention index (RI [%/min]). To identify predictors of regional 11C-HED RI in HFpEF patients, we proposed a multivariate mixed-effects model for repeated measures over segments with an unstructured covariance matrix. Results: Global 11C-HED RI was significantly lower and more heterogeneous in HFpEF patients versus volunteers (P < 0.01 for all). Regional 11C-HED RI correlated positively with systolic wall thickening (r = 0.42, P < 0.001) and negatively with the extent of LGE (r = -0.43, P < 0.001). Segments with large extent of LGE in HFpEF patients had the lowest regional 11C-HED RI among all segments (P < 0.001 for post hoc tests). Multivariate analysis demonstrated that systolic wall thickening and the extent of LGE were significant predictors of regional 11C-HED RI in HFpEF patients (both P ≤ 0.001). Conclusion: Regional sympathetic denervation was associated with contractile dysfunction and fibrotic burden in HFpEF patients, suggesting that regional sympathetic denervation may provide an integrated measure of myocardial damage in HFpEF.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	1619-7070
関連情報	PMID 28653180
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00259-017-3760-y