Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study

Aikawa, Tadao; Oyama-Manabe, Noriko; Naya, Masanao; Ohira, Hiroshi; Sugimoto, Ayako; Tsujino, Ichizo; Obara, Masahiko; Manabe, Osamu; Kudo, Kohsuke; Tsutsui, Hiroyuki; Tamaki, Nagara

Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study

Aikawa, Tadao; Oyama-Manabe, Noriko; Naya, Masanao et al.

European Radiology, 2017, 27(10), 4054-4063

Permalink : https://hdl.handle.net/2115/71561

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アクセス権	open access
URI	https://hdl.handle.net/2115/71561
タイトル	Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study
著者	Aikawa, Tadao ; Oyama-Manabe, Noriko ; Naya, Masanao ; Ohira, Hiroshi ; Sugimoto, Ayako ; Tsujino, Ichizo ; Obara, Masahiko ; Manabe, Osamu ; Kudo, Kohsuke ; Tsutsui, Hiroyuki ; Tamaki, Nagara
e-Rad_Researcher 20795059 著者名 Aikawa, Tadao
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 20455637 著者名 Naya, Masanao
著者名 Ohira, Hiroshi
著者名 Sugimoto, Ayako
e-Rad_Researcher 00344507 著者名 Tsujino, Ichizo
著者名 Obara, Masahiko
e-Rad_Researcher 40443957 著者名 Manabe, Osamu
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	Cardiac sarcoidosis
	Cardiac CT
	Delayed enhancement
	Myocardium
	Iterative reconstruction
発行日	2017-10
出版者	Springer
収録物名	European Radiology
巻(号)	27(10)
ページ	4054-4063
抄録	Objectives: To evaluate the diagnostic value of delayed contrast-enhanced computed tomography (DE-CT) for cardiac sarcoidosis (CS) in patients with or without implantable devices, including a quantitative comparison with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). Methods: Twenty-four patients (mean age, 64 ± 9 years; 17 women) with known or suspected CS underwent retrospective electrocardiogram-gated DE-CT at 80 kV with knowledge-based iterative model reconstruction. Fourteen patients without implantable devices also underwent LGE-CMR, while ten with pacemakers or implantable cardioverter-defibrillators did not. The presence of hyperenhanced myocardium was assessed visually and quantitatively using a 5-standard deviation threshold above the mean of remote myocardium. Results: Inter-observer agreement for visual detection of hyperenhanced segments on DE-CT was excellent in patients with implantable devices and in those without (κ = 0.91 and κ = 0.94, respectively). Comparisons of the percent area of hyperenhanced myocardium between DE-CT and LGE-CMR on both per-patient and per-segment analyses showed good correlations (r = 0.96 and r = 0.83, respectively; p < 0.001). The sensitivity and specificity of DE-CT for the diagnosis of CS were 94% and 33%. Conclusions: The extent of hyperenhanced lesion with DE-CT showed good agreement with LGE-CMR results. DE-CT showed high sensitivity for detecting CS and may be useful particularly in patients with contraindications to CMR.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0938-7994
関連情報	PMID 28382537
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00330-017-4824-x