Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

Itoh, Sachiko; Araki, Atsuko; Mitsui, Takahiko; Miyashita, Chihiro; Goudarzi, Houman; Sasaki, Seiko; Cho, Kazutoshi; Nakazawa, Hiroyuki; Iwasaki, Yusuke; Shinohara, Nobuo; Nonomura, Katsuya; Kishi, Reiko

Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

Itoh, Sachiko; Araki, Atsuko; Mitsui, Takahiko et al.

Environment International, 2016, 94, 51-59

Permalink : https://hdl.handle.net/2115/71600

このアイテムのアクセス数:1,097件（2026-08-08 06:31 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
1-s2.0-S0160412016301842-mmc2	doc	1.65 MB	299	Supplemental Figures
1-s2.0-S0160412016301842-mmc1	doc	168 KB	442	Supplemental tables
ENVINT-D-15-01711R2(3)(1)-2	pdf	722 KB	1,338

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/71600
タイトル	Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health
その他のタイトル	PFASs and cord blood reproductive hormone levels
著者	Itoh, Sachiko ; Araki, Atsuko ; Mitsui, Takahiko ; Miyashita, Chihiro ; Goudarzi, Houman ; Sasaki, Seiko ; Cho, Kazutoshi ; Nakazawa, Hiroyuki ; Iwasaki, Yusuke ; Shinohara, Nobuo ; Nonomura, Katsuya ; Kishi, Reiko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 90421966 著者名 Mitsui, Takahiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
e-Rad_Researcher 50150173 著者名 Nakazawa, Hiroyuki
e-Rad_Researcher 10409360 著者名 Iwasaki, Yusuke
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
e-Rad_Researcher 60113750 著者名 Nonomura, Katsuya
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Perfluoroalkyl substances
	Reproductive hormones
	Cord blood
	Prenatal exposure
	Birth cohort
発行日	2016-09
出版者	Elsevier
収録物名	Environment International
巻(号)	94
ページ	51-59
抄録	Background: Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones. Objective: To explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones. Methods: In the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother-infant pairs recruited in 2002-2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography-tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL). Results: The median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels. Conclusions: These results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0160-4120
関連情報	PMID 27209000
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envint.2016.05.011