Heterogeneous genetic make-up of Japanese house mice (Mus musculus) created by multiple independent introductions and spatio-temporally diverse hybridization processes

Kuwayama, Takashi; Nunome, Mitsuo; Kinoshita, Gohta; Abe, Kuniya; Suzuki, Hitoshi

Heterogeneous genetic make-up of Japanese house mice (Mus musculus) created by multiple independent introductions and spatio-temporally diverse hybridization processes

Kuwayama, Takashi; Nunome, Mitsuo; Kinoshita, Gohta et al.

Biological journal of the Linnean Society, 2017, 122(3), 661-674

Permalink : https://hdl.handle.net/2115/71740

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アクセス権	open access
URI	https://hdl.handle.net/2115/71740
タイトル	Heterogeneous genetic make-up of Japanese house mice (Mus musculus) created by multiple independent introductions and spatio-temporally diverse hybridization processes
著者	Kuwayama, Takashi ; Nunome, Mitsuo ; Kinoshita, Gohta ; Abe, Kuniya ; Suzuki, Hitoshi
著者名 Kuwayama, Takashi
e-Rad_Researcher 40609715 著者名 Nunome, Mitsuo
著者名 Kinoshita, Gohta
著者名 Abe, Kuniya
e-Rad_Researcher 40179239 著者名 Suzuki, Hitoshi
言語	英語
キーワード	Mus musculus
	nuclear gene haplotype
	peopling of Japan
	recombination
	secondary contact
発行日	2017-11
出版者	Oxford University Press
収録物名	Biological journal of the Linnean Society
巻(号)	122(3)
ページ	661-674
抄録	In this study, phylogenetic analysis of relatively long sequences of mitochondrial DNA (4225 bp) in the Japanese house mouse Mus musculus provides the first evidence that both southern Asian subspecies of Mus musculus castaneus (CAS) and northern Asian subspecies of Mus musculus musculus (MUS) arrived in Japan through rapid population expansion events, from Southern China similar to 4000 years ago and the Korean Peninsula similar to 2000 years ago, respectively. Nuclear DNA haplotype structure analyses targeting a chromosome region with two different tract sizes, 1 and 5 Mb, consisting of nine and six tandemly arranged markers, respectively, yielded a possible average fragment length of 170 kb of CAS haplotypes in the MUS background genome in northern Japan, providing a rough estimate of its elapsed time of 815 generations under an assumption of continued backcrossing. Less frequent and shortened CAS-like haplotypes specific to Japan were detected, suggesting ancient introduction prior to the appearance of the South Chinese CAS in Japan. Our analyses also showed sporadic appearance of long fragments (2-5 Mb) from the west European subspecies Mus musculus domesticus, indicating contemporary stowaway introduction. Overall, multiple overseas introductions, and the time-lagged inter-subspecies genetic admixture, probably resulted in the heterogeneous state of Japanese wild mice.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Biological Journal of the Linnean Society following peer review. The version of record Biological Journal of the Linnean Society, Volume 122, Issue 3, 25 October 2017, Pages 661–674 is available online at: https://doi.org/10.1093/biolinnean/blx076.
PISSN	0024-4066
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/biolinnean/blx076