Computer-Based Radiographic Quantification of Joint Space Narrowing Progression Using Sequential Hand Radiographs : Validation Study in Rheumatoid Arthritis Patients from Multiple Institutions

Ichikawa, Shota; Kamishima, Tamotsu; Sutherland, Kenneth; Fukae, Jun; Katayama, Kou; Aoki, Yuko; Okubo, Takanobu; Okino, Taichi; Kaneda, Takahiko; Takagi, Satoshi; Tanimura, Kazuhide

Computer-Based Radiographic Quantification of Joint Space Narrowing Progression Using Sequential Hand Radiographs : Validation Study in Rheumatoid Arthritis Patients from Multiple Institutions

Ichikawa, Shota; Kamishima, Tamotsu; Sutherland, Kenneth et al.

Journal of digital imaging, 2017, 30(5), 648-656

Permalink : https://hdl.handle.net/2115/71769

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アクセス権	open access
URI	https://hdl.handle.net/2115/71769
タイトル	Computer-Based Radiographic Quantification of Joint Space Narrowing Progression Using Sequential Hand Radiographs : Validation Study in Rheumatoid Arthritis Patients from Multiple Institutions
著者	Ichikawa, Shota ; Kamishima, Tamotsu ; Sutherland, Kenneth ; Fukae, Jun ; Katayama, Kou ; Aoki, Yuko ; Okubo, Takanobu ; Okino, Taichi ; Kaneda, Takahiko ; Takagi, Satoshi ; Tanimura, Kazuhide
著者名 Ichikawa, Shota
e-Rad_Researcher 10399868 著者名 Kamishima, Tamotsu
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth
著者名 Fukae, Jun
著者名 Katayama, Kou
著者名 Aoki, Yuko
著者名 Okubo, Takanobu
著者名 Okino, Taichi
著者名 Kaneda, Takahiko
e-Rad_Researcher 50396305 著者名 Takagi, Satoshi
著者名 Tanimura, Kazuhide
言語	英語
キーワード	Radiography
	Computer assisted detection
	Hand
発行日	2017-10
出版者	Springer
収録物名	Journal of digital imaging
巻(号)	30(5)
ページ	648-656
抄録	We have developed a refined computer-based method to detect joint space narrowing (JSN) progression with the joint space narrowing progression index (JSNPI) by superimposing sequential hand radiographs. The purpose of this study is to assess the validity of a computer-based method using images obtained from multiple institutions in rheumatoid arthritis (RA) patients. Sequential hand radiographs of 42 patients (37 females and 5 males) with RA from two institutions were analyzed by a computer-based method and visual scoring systems as a standard of reference. The JSNPI above the smallest detectable difference (SDD) defined JSN progression on the joint level. The sensitivity and specificity of the computer-based method for JSN progression was calculated using the SDD and a receiver operating characteristic (ROC) curve. Out of 314 metacarpophalangeal joints, 34 joints progressed based on the SDD, while 11 joints widened. Twenty-one joints progressed in the computer-based method, 11 joints in the scoring systems, and 13 joints in both methods. Based on the SDD, we found lower sensitivity and higher specificity with 54.2 and 92.8%, respectively. At the most discriminant cutoff point according to the ROC curve, the sensitivity and specificity was 70.8 and 81.7%, respectively. The proposed computer-based method provides quantitative measurement of JSN progression using sequential hand radiographs and may be a useful tool in follow-up assessment of joint damage in RA patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Journal of digital imaging. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10278-017-9970-9.
PISSN	0897-1889
EISSN	1618-727X
関連情報	PMID 28378032
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10278-017-9970-9