Tetraploidy-associated centrosome overduplication in mouse early embryos

Yaguchi, Kan; Yamamoto, Takahiro; Matsui, Ryo et al.

Communicative & Integrative Biology, 2018, 11(4), e1526605-1-e1526605-4

Permalink : https://hdl.handle.net/2115/71776

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アクセス権
open access
URI
https://hdl.handle.net/2115/71776
タイトル
Tetraploidy-associated centrosome overduplication in mouse early embryos
著者
Yaguchi, Kan ; Yamamoto, Takahiro ; Matsui, Ryo ; Shimada, Masaya ; Shibanuma, Atsuko ; Kamimura, Keiko ; Koda, Toshiaki ; Uehara, Ryota
著者名
Yaguchi, Kan
著者名
Yamamoto, Takahiro
著者名
Matsui, Ryo
著者名
Shimada, Masaya
著者名
Shibanuma, Atsuko
著者名
Kamimura, Keiko
著者名
Koda, Toshiaki
e-Rad_Researcher
20580020
著者名
Uehara, Ryota
言語
英語
キーワード
Tetraploid
centrosome
mouse embryo
発行日
2018-10-02
収録物名
Communicative & Integrative Biology
巻(号)
11(4)
ページ
e1526605-1-e1526605-4
抄録
Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
EISSN
1942-0889
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1080/19420889.2018.1526605