Performance of computed tomography-derived pulmonary vasculature metrics in the diagnosis and haemodynamic assessment of pulmonary arterial hypertension

Shimizu, Kaoruko; Tsujino, Ichizo; Sato, Takahiro; Sugimoto, Ayako; Nakaya, Toshitaka; Watanabe, Taku; Ohira, Hiroshi; Ito, Yoichi M.; Nishimura, Masaharu

Performance of computed tomography-derived pulmonary vasculature metrics in the diagnosis and haemodynamic assessment of pulmonary arterial hypertension

Shimizu, Kaoruko; Tsujino, Ichizo; Sato, Takahiro et al.

European journal of radiology, 2017, 96, 31-38

Permalink : https://hdl.handle.net/2115/71784

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アクセス権	open access
URI	https://hdl.handle.net/2115/71784
タイトル	Performance of computed tomography-derived pulmonary vasculature metrics in the diagnosis and haemodynamic assessment of pulmonary arterial hypertension
著者	Shimizu, Kaoruko ; Tsujino, Ichizo ; Sato, Takahiro ; Sugimoto, Ayako ; Nakaya, Toshitaka ; Watanabe, Taku ; Ohira, Hiroshi ; Ito, Yoichi M. ; Nishimura, Masaharu
e-Rad_Researcher 40399853 著者名 Shimizu, Kaoruko
e-Rad_Researcher 00344507 著者名 Tsujino, Ichizo
著者名 Sato, Takahiro
著者名 Sugimoto, Ayako
著者名 Nakaya, Toshitaka
e-Rad_Researcher 90399949 著者名 Watanabe, Taku
e-Rad_Researcher 20528301 著者名 Ohira, Hiroshi
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	Pulmonary arterial hypertension
	Pulmonary vasculature
	Pulmonary vein
	Computed tomography (CT)
	Diagnosis
	Haemodynamic assessment
発行日	2017-11
出版者	Elsevier
収録物名	European journal of radiology
巻(号)	96
ページ	31-38
抄録	Background: Few studies have addressed the value of combining computed tomography-derived pulmonary vasculature metrics for the diagnosis and haemodynamic evaluation of pulmonary arterial hypertension (PAH). Materials and methods: We measured three computed tomography parameters for the pulmonary artery, peripheral vessels, and pulmonary veins: the ratio of the diameter of the pulmonary artery to the aorta (PA/Ao), the cross-sectional area of small pulmonary vessels <5 mm2 as a percentage of total lung area (%CSA<5), and the diameter of the right inferior pulmonary vein (PVD). The measured quantities were compared between patients with PAH (n = 45) and control subjects (n = 56), and their diagnostic performance and associations with PAH-related clinical indices, including right heart catheterization measurements, were examined. Results: PA/Ao and %CSA<5 were significantly higher in patients with PAH than in controls. Receiver-operating characteristic curve analysis for ability to diagnose PAH showed a high area under the curve (AUC) for PA/Ao (0.95) and modest AUCs for %CSA<5 (0.75) and PVD (0.56). PA/Ao correlated positively with mean pulmonary arterial pressure and PVD correlated negatively with pulmonary vascular resistance. The %CSA<5 correlated negatively with mean pulmonary arterial pressure and pulmonary vascular resistance and positively with cardiac index. Notably, the PA/Ao and PVD values divided by %CSA<5 correlated better with right heart catheterization indices than the non-divided values. Conclusion: PA/Ao, %CSA<5, and PVD are useful non-invasive pulmonary vasculature metrics, both alone and in combination, for diagnosis and haemodynamic assessment of PAH.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0720-048X
関連情報	PMID 29103472
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ejrad.2017.09.010