Serum adiponectin and insulin secretion : A direct or inverse association?

Nakamura, Akinobu; Miyoshi, Hideaki; Ukawa, Shigekazu et al.

Journal of diabetes investigation, 2018, 9(5), 1106-1109

Permalink : https://hdl.handle.net/2115/71862

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アクセス権
open access
URI
https://hdl.handle.net/2115/71862
タイトル
Serum adiponectin and insulin secretion : A direct or inverse association?
著者
Nakamura, Akinobu ; Miyoshi, Hideaki ; Ukawa, Shigekazu ; Nakamura, Koshi ; Nakagawa, Takafumi ; Terauchi, Yasuo ; Tamakoshi, Akiko ; Atsumi, Tatsuya
e-Rad_Researcher
70552420
著者名
Nakamura, Akinobu
e-Rad_Researcher
30360902
著者名
Miyoshi, Hideaki
e-Rad_Researcher
40706751
著者名
Ukawa, Shigekazu
e-Rad_Researcher
80422898
著者名
Nakamura, Koshi
著者名
Nakagawa, Takafumi
著者名
Terauchi, Yasuo
e-Rad_Researcher
90236737
著者名
Tamakoshi, Akiko
e-Rad_Researcher
20301905
著者名
Atsumi, Tatsuya
言語
英語
キーワード
Adiponectin
Disposition index
Insulin secretion
発行日
2018-09
出版者
John Wiley & Sons
収録物名
Journal of diabetes investigation
巻(号)
9(5)
ページ
1106-1109
抄録
We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of β-cell function ± adjustment for insulin resistance using the disposition index. Multivariate analysis showed that HMW adiponectin was significantly and inversely associated with homeostasis model assessment of β-cell function (partial regression coefficient -0.19, 95% confidence interval -0.28, -0.10, P < 0.0001). However, HMW adiponectin was significantly and positively associated with disposition index (partial regression coefficient 0.15, 95% confidence interval 0.06, 0.24, P = 0.0016). The present study showed that a positive association between HMW adiponectin levels and insulin secretion evaluated using an index incorporating adjustment for insulin resistance was identified, and vice versa using an index that did not adjust for insulin resistance.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial 4.0 International
PISSN
2040-1116
EISSN
2040-1124
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1111/jdi.12821