Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers

Okabe, Hiroaki; Shimizu, Chikara; Yamamoto, Maiko; Kikuchi, Rei; Minami, Akiko; Chen, Yi-Fan; Imai, Hideyuki; Mizuta, Masahiro; Chen, Zhen; Chiba, Hitoshi; Hui, Shu-Ping

Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers

Okabe, Hiroaki; Shimizu, Chikara; Yamamoto, Maiko et al.

Analytical sciences, 2018, 34(9), 1043-1047

Permalink : https://hdl.handle.net/2115/71895

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アクセス権	open access
URI	https://hdl.handle.net/2115/71895
タイトル	Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers
著者	Okabe, Hiroaki ; Shimizu, Chikara ; Yamamoto, Maiko ; Kikuchi, Rei ; Minami, Akiko ; Chen, Yi-Fan ; Imai, Hideyuki ; Mizuta, Masahiro ; Chen, Zhen ; Chiba, Hitoshi ; Hui, Shu-Ping
著者名 Okabe, Hiroaki
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
著者名 Yamamoto, Maiko
著者名 Kikuchi, Rei
著者名 Minami, Akiko
著者名 Chen, Yi-Fan
e-Rad_Researcher 10213216 著者名 Imai, Hideyuki
e-Rad_Researcher 70174026 著者名 Mizuta, Masahiro
著者名 Chen, Zhen
e-Rad_Researcher 70197622 著者名 Chiba, Hitoshi
e-Rad_Researcher 90337030 著者名 Hui, Shu-Ping
言語	英語
キーワード	25-Hydroxy vitamin D-3
	LC/MS/MS
	UV-B
	monthly variation
発行日	2018-09-10
出版者	日本分析化学会
出版者	Japan Society for Analytical Chemistry
収録物名	Analytical sciences
巻(号)	34(9)
ページ	1043-1047
抄録	25-Hydroxyvitamin D-3 (25(OH)D-3) as the metabolite of vitamin D, is connected with various of diseases, and important to people with limited sunshine. Thus, the investigation of serum 25-hydroxyvitamin D and its variation in these people is necessary. In this study, a simple, precise, and accurate method for serum 25(OH)D-3 determination by LC/MS/MS was developed. Serum samples were obtained monthly for one year from 11 male and 11 female indoor workers in Sapporo, Japan, and the overall 25(OH)D-3 concentration was 12.9 +/- 4.7 ng/mL. The 25(OH)D-3 in females was significantly lower than that in males (14.0 +/- 5.0 vs. 11.9 +/- 4.3 ng/mL). The serum 25(OH)D-3 concentration in males and females were both strongly correlated to UV-B radiation (r(2) = 0.8477 and 0.7384, respectively), with a two-month's lag. Also the monthly change in 25(OH)D-3 in males was more significant than that in females.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0910-6340
NCID	AA10500785
関連情報	PMID 29863032
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2116/analsci.18P193