Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates : The Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Yamamoto, Jun; Matsumura, Toru; Mitsui, Takahiko; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Minakami, Hisanori; Shinohara, Nobuo; Kishi, Reiko

Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates : The Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Sasaki, Seiko; Araki, Atsuko et al.

Epidemiology, 2017, 28, S3-S9

Permalink : https://hdl.handle.net/2115/71997

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アクセス権	open access
URI	https://hdl.handle.net/2115/71997
タイトル	Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates : The Hokkaido Study on Environment and Children's Health
その他のタイトル	Cord blood BPA and reproductive and thyroid hormone levels of neonates
著者	Minatoya, Machiko ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Itoh, Sachiko ; Yamamoto, Jun ; Matsumura, Toru ; Mitsui, Takahiko ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Minakami, Hisanori ; Shinohara, Nobuo ; Kishi, Reiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
著者名 Yamamoto, Jun
著者名 Matsumura, Toru
著者名 Mitsui, Takahiko
e-Rad_Researcher 20374233 著者名 Moriya, Kimihiko
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
著者名 Morioka, Keita
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
発行日	2017-10
出版者	Wolters Kluwer
収録物名	Epidemiology
巻(号)	28
ページ	S3-S9
抄録	Background: Bisphenol A (BPA) is widely used and BPA exposure is nearly ubiquitous in developed countries. While animal studies have indicated adverse health effects of prenatal BPA exposure including reproductive dysfunction and thyroid function disruption possibly in sex-specific manner, findings from epidemiological studies have not been enough to proof these adverse effects. Given very limited research on human, the aim of this study was to investigate associations between cord blood BPA levels and reproductive and thyroid hormone levels of neonates and whether associations differed by neonate sex. Methods: Among 514 participants of the Hokkaido study who were recruited from 2002 to 2005 at one hospital in Sapporo, Japan. BPA level in cord blood was determined by ID-LC/MS/MS and the limit of quantification was 0.040 ng/ml. 9 types of reproductive hormone levels in cord blood were measured and thyroid hormone levels were obtained from neonate mass screening test data. 283 subjects those who had both BPA and hormone levels measurements were included for the final analyses. Results: Geometric mean of cord blood BPA was 0.051 ng/ml. After adjustment, BPA level was negatively associated with prolactin (PRL) (β=-0.38). There was an interaction between infant sex and BPA levels on PRL, weak negative association was found in boys (β=-0.12) whereas weak positive association was found in girls (β=0.14). BPA level showed weak positive association with testosterone, estradiol and progesterone levels in boys. No association was found between BPA and thyroid hormone levels. Conclusions: Our findings suggested that fetal BPA levels might be associated with certain reproductive hormone levels of neonate with sex-specific manner, though further investigations are necessary.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a non-final version of an article published in final form in Epidemiology: October 2017, Vol. 28, pp.S3–S9.
PISSN	1044-3983
関連情報	PMID 29028670
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1097/EDE.0000000000000716