open access

https://hdl.handle.net/2115/71998

JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise

英語

Neural progenitors

2018-08-20

Nature Publishing Group

Scientific reports

8

12484

Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.

学術雑誌論文

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Creative Commons Attribution 4.0 International

2045-2322