Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants : The Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Nakajima, Sonomi; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Ikeno, Tamiko; Nakajima, Tamie; Goto, Yuko; Kishi, Reiko

Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants : The Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Nakajima, Sonomi; Sasaki, Seiko et al.

Science of The Total Environment, 2016, 565, 1037-1043

Permalink : https://hdl.handle.net/2115/71999

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アクセス権	open access
URI	https://hdl.handle.net/2115/71999
タイトル	Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants : The Hokkaido Study on Environment and Children's Health
著者	Minatoya, Machiko ; Nakajima, Sonomi ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ikeno, Tamiko ; Nakajima, Tamie ; Goto, Yuko ; Kishi, Reiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
著者名 Nakajima, Sonomi
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
著者名 Nakajima, Tamie
著者名 Goto, Yuko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Di (2-ethylhexyl) phthalate
	Thyroid hormone
	Neurodevelopment
	Prenatal Exposure
発行日	2016-09-15
出版者	Elsevier
収録物名	Science of The Total Environment
巻(号)	565
ページ	1037-1043
抄録	Di (2-ethylhexyl) phthalate (DEHP) is commonly used phthalates and concerns of adverse effects of prenatal DEHP exposure on neonatal thyroid hormone (TH) and neurodevelopment are increasing. However, there is no report regarding association between prenatal DEHP exposure and infant neurodevelopment including TH levels in Japanese population. Thus the aim of present study was to evaluate the associations between prenatal DEHP exposure and mental and psychomotor development of infants 6 and 18 months along with investigating influence on neonatal free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels in the prospective birth cohort study. Maternal blood samples collected between 23-41 weeks of gestation was analyzed for mono (2-ethylhexyl) phthalate (MEHP), metabolite of DEHP levels. Neonatal FT4 and TSH were obtained from mass screening data. Infant neurodevelopment was assessed by Bayley Scale of Infant Development second edition at 6 and 18 month of age. For the final analysis, 328 participants were included. The median levels of maternal MEHP was 10.6 ng/ml, neonatal TSH and FT4 was 2.20 μU/ml and 2.03 ng/ml, respectively. We did not find any associations between prenatal DEHP exposure and neonatal TH levels or infant mental and psychomotor development at 6 and 18 month. In this study, prenatal DEHP exposure did not show adverse effects on infant TH levels or mental and psychomotor development in early life stage. However, our previous study revealed negative effects of prenatal DEHP exposure on sex hormone levels, continuous investigation on neurodevelopment in later life in association with prenatal DEHP exposure is necessary.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報	PMID 27261429
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2016.05.098