Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health

Kato, Shizue; Itoh, Sachiko; Yuasa, Motoyuki; Baba, Toshiaki; Miyashita, Chihiro; Sasaki, Seiko; Nakajima, Sonomi; Uno, Akiko; Nakazawa, Hiroyuki; Iwasaki, Yusuke; Okada, Emiko; Kishi, Reiko

Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health

Kato, Shizue; Itoh, Sachiko; Yuasa, Motoyuki et al.

Environmental Health and Preventive Medicine, 2016, 21(5), 334-344

Permalink : https://hdl.handle.net/2115/72001

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アクセス権	open access
URI	https://hdl.handle.net/2115/72001
タイトル	Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health
著者	Kato, Shizue ; Itoh, Sachiko ; Yuasa, Motoyuki ; Baba, Toshiaki ; Miyashita, Chihiro ; Sasaki, Seiko ; Nakajima, Sonomi ; Uno, Akiko ; Nakazawa, Hiroyuki ; Iwasaki, Yusuke ; Okada, Emiko ; Kishi, Reiko
著者名 Kato, Shizue
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 30463748 著者名 Yuasa, Motoyuki
著者名 Baba, Toshiaki
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Nakajima, Sonomi
著者名 Uno, Akiko
e-Rad_Researcher 50150173 著者名 Nakazawa, Hiroyuki
e-Rad_Researcher 10409360 著者名 Iwasaki, Yusuke
e-Rad_Researcher 00766537 著者名 Okada, Emiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Perfluorooctane sulfonate
	perfluorooctanoate
	thyroid hormones
	mother-infant pairs
	prenatal exposure
発行日	2016-09
出版者	Springer
収録物名	Environmental Health and Preventive Medicine
巻(号)	21(5)
ページ	334-344
抄録	Objectives: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been widely used as industrial products, and are persistent organic pollutants due to their chemical stability. Previous studies suggested that PFOS and PFOA might disrupt thyroid hormone (TH) status. Although TH plays an important role in fetal growth during pregnancy, little attention has been paid to the relationships between maternal exposure to perfluorocarbons and TH statuses of mothers and fetuses. We investigated the effects of low levels of environmental PFOS and PFOA on thyroid function of mothers and infants. Methods: Of the eligible subjects in a prospective cohort, 392 mother-infant pairs were selected. Concentration of maternal serum PFOS and PFOA was measured in samples taken during the second and third trimesters or within 1 week of delivery. Blood samples for measuring thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers at early gestational stage (Median; 11.1 weeks), and from infants between 4 and 7 days of age, respectively. Results: Median concentrations of PFOS and PFOA were 5.2 (95% confidence interval [CI]]: 1.6-12.3) and 1.2 (95% CI: limitation of detection-3.4) ng/mL, respectively. Maternal PFOS levels were inversely correlated with maternal serum TSH and positively associated with infant serum TSH, whereas maternal PFOA showed no significant relationship with TSH or FT4 among mothers and infants. Conclusions: These findings suggest that PFOS may independently affect the secretion and balances of maternal and infant TSH even at low levels of environmental exposure.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	1342-078X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12199-016-0534-2