STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Kitai, Yuichi; Iwakami, Masashi; Saitoh, Kodai; Togi, Sumihito; Isayama, Serina; Sekine, Yuichi; Muromoto, Ryuta; Kashiwakura, Jun-ichi; Yoshimura, Akihiko; Oritani, Kenji; Matsuda, Tadashi

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Kitai, Yuichi; Iwakami, Masashi; Saitoh, Kodai et al.

Journal of Biological Chemistry (JBC), 2017, 292(47), 19392-19399

Permalink : https://hdl.handle.net/2115/72029

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アクセス権	open access
URI	https://hdl.handle.net/2115/72029
タイトル	STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization
著者	Kitai, Yuichi ; Iwakami, Masashi ; Saitoh, Kodai ; Togi, Sumihito ; Isayama, Serina ; Sekine, Yuichi ; Muromoto, Ryuta ; Kashiwakura, Jun-ichi ; Yoshimura, Akihiko ; Oritani, Kenji ; Matsuda, Tadashi
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
著者名 Iwakami, Masashi
著者名 Saitoh, Kodai
著者名 Togi, Sumihito
著者名 Isayama, Serina
著者名 Sekine, Yuichi
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
著者名 Kashiwakura, Jun-ichi
著者名 Yoshimura, Akihiko
著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	adaptor protein
	prostate cancer
	protein degradation
	signal transduction
	STAT3
	c-CBL
発行日	2017-11-24
出版者	American Society for Biochemistry and Molecular Biology (ASBMB)
収録物名	Journal of Biological Chemistry (JBC)
巻(号)	292(47)
ページ	19392-19399
抄録	Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signaling pathways and promotes tumorigenesis in melanoma and breast cancer cells. However, the contribution of STAP-2 to the behavior of other types of cancer cells is unclear. Here, we show that STAP-2 promotes tumorigenesis of prostate cancer cells through up-regulation of EGF receptor (EGFR) signaling. Tumor growth of a prostate cancer cell line, DU145, was strongly decreased by STAP-2 knockdown. EGF-induced gene expression and phosphorylation of AKT, ERK, and STAT3 were significantly decreased in STAP-2-knockdown DU145 cells. Mechanistically, we found that STAP-2 interacted with EGFR and enhanced its stability by inhibiting c-CBL-mediated EGFR ubiquitination. Our results indicate that STAP-2 promotes prostate cancer progression via facilitating EGFR activation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	This research was originally published in J. Biol. Chem. Kitai,Yuichi et al. STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization. J. Biol. Chem. 2017; 292(47):19392-19399. © the American Society for Biochemistry and Molecular Biology.
PISSN	0021-9258
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1074/jbc.M117.802884