Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

Deyama, Satoshi; Shimoda, Kento; Ikeda, Hiroyuki; Fukuda, Hayato; Shuto, Satoshi; Minami, Masabumi

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

Deyama, Satoshi; Shimoda, Kento; Ikeda, Hiroyuki et al.

Journal of pharmacological sciences, 2018, 138(1), 86-88

Permalink : https://hdl.handle.net/2115/72037

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アクセス権	open access
URI	https://hdl.handle.net/2115/72037
タイトル	Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
著者	Deyama, Satoshi ; Shimoda, Kento ; Ikeda, Hiroyuki ; Fukuda, Hayato ; Shuto, Satoshi ; Minami, Masabumi
著者名 Deyama, Satoshi
著者名 Shimoda, Kento
著者名 Ikeda, Hiroyuki
著者名 Fukuda, Hayato
e-Rad_Researcher 70241346 著者名 Shuto, Satoshi
e-Rad_Researcher 20243040 著者名 Minami, Masabumi
言語	英語
キーワード	Antidepressant
	omega-3 polyunsaturated fatty acid
	Resolvin
発行日	2018-09
出版者	Japanese Pharmacological Society
収録物名	Journal of pharmacological sciences
巻(号)	138(1)
ページ	86-88
抄録	Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. (C) 2018 The Authors. Production and hosting by Elsevier B.V.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1347-8613
関連情報	PMID 30293959
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.jphs.2018.09.006