Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Nishida, Mutsumi; Kahata, Kaoru; Hayase, Eiko; Shigematsu, Akio; Sato, Megumi; Kudo, Yusuke; Omotehara, Satomi; Iwai, Takahito; Sugita, Junichi; Shibuya, Hitoshi; Shimizu, Chikara; Teshima, Takanori

Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Nishida, Mutsumi; Kahata, Kaoru; Hayase, Eiko et al.

Biology of blood and marrow transplantation, 2018, 24(9), 1896-1900

Permalink : https://hdl.handle.net/2115/72046

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アクセス権	open access
URI	https://hdl.handle.net/2115/72046
タイトル	Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation
著者	Nishida, Mutsumi ; Kahata, Kaoru ; Hayase, Eiko ; Shigematsu, Akio ; Sato, Megumi ; Kudo, Yusuke ; Omotehara, Satomi ; Iwai, Takahito ; Sugita, Junichi ; Shibuya, Hitoshi ; Shimizu, Chikara ; Teshima, Takanori
e-Rad_Researcher 90404722 著者名 Nishida, Mutsumi
著者名 Kahata, Kaoru
著者名 Hayase, Eiko
著者名 Shigematsu, Akio
著者名 Sato, Megumi
著者名 Kudo, Yusuke
著者名 Omotehara, Satomi
著者名 Iwai, Takahito
著者名 Sugita, Junichi
著者名 Shibuya, Hitoshi
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	Sinusoidal obstruction syndrome
	Hepatic veno-occlusive disease
	Ultrasonography
	Color Doppler
	Hematopoietic stem cell transplantation
発行日	2018-09
出版者	Elsevier
収録物名	Biology of blood and marrow transplantation
巻(号)	24(9)
ページ	1896-1900
抄録	Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to uni-variate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1083-8791
関連情報	PMID 29803752
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.bbmt.2018.05.025