open access

https://hdl.handle.net/2115/72075

Complement-independent blistering mechanisms in bullous pemphigoid

英語

complement

2017-12

John Wiley & Sons

Experimental dermatology

26(12)

1235-1239

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that clinically demonstrates tense blisters with widespread erythema, histologically demonstrates subepidermal blistering and immunologically demonstrates the presence of circulating autoantibodies against hemidesmosomal molecules. Complement activation has long been regarded as necessary for the generation of the BP, However, certain evidence has recently come to support non-complemental blistering mechanisms. The story of BP blistering mechanisms is a complicated one. This review mainly focuses on a specific blistering mechanism that highlights the role of complements in BP blistering.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Iwata H, Ujiie H. Complement‐independent blistering mechanisms in bullous pemphigoid. Exp Dermatol. 2017;26:1235–1239, which has been published in final form at https://doi.org/10.1111/exd.13367. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

0906-6705