Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes

Imafuku, Keisuke; Iwata, Hiroaki; Kamaguchi, Mayumi; Izumi, Kentaro; Natsuga, Ken; Ujiie, Hideyuki; Nishie, Wataru; Shimizu, Hiroshi

Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes

Imafuku, Keisuke; Iwata, Hiroaki; Kamaguchi, Mayumi et al.

Experimental dermatology, 2017, 26(12), 1171-1174

Permalink : https://hdl.handle.net/2115/72076

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/72076
タイトル	Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes
その他のタイトル	non-NC16A bullous pemphigoid
著者	Imafuku, Keisuke ; Iwata, Hiroaki ; Kamaguchi, Mayumi ; Izumi, Kentaro ; Natsuga, Ken ; Ujiie, Hideyuki ; Nishie, Wataru ; Shimizu, Hiroshi
著者名 Imafuku, Keisuke
e-Rad_Researcher 20397334 著者名 Iwata, Hiroaki
著者名 Kamaguchi, Mayumi
e-Rad_Researcher 50793668 著者名 Izumi, Kentaro
e-Rad_Researcher 70645457 著者名 Natsuga, Ken
e-Rad_Researcher 60374435 著者名 Ujiie, Hideyuki
e-Rad_Researcher 20443955 著者名 Nishie, Wataru
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
言語	英語
キーワード	bullous pemphigoid
	depletion
	internalization
	non-collagenous 16A domain
	type XVII collagen
発行日	2017-12
出版者	John Wiley & Sons
収録物名	Experimental dermatology
巻(号)	26(12)
ページ	1171-1174
記述	Special Issue: Thematic issue: New insights into pemphigoid diseases
抄録	Type XVII collagen (COL17) and the non-collagenous 16A (NC16A) domain is regarded as the major pathogenic domains for bullous pemphigoid (BP). Some patients with BP have autoantibodies against parts of COL17 outside the NC16A domain (hereinafter the non-NC16A domain) and show less inflammatory manifestations. There were no significant differences in titres and IgG subclasses between NC16A-BP and non-NC16A-BP as determined by indirect immunofluorescent microscopy. The neutrophil activation capacities determined by ROS release did not differ between NC16A-BP and non-NC16A-BP. However, NC16A-BP IgG depleted COL17 in a dose-dependent manner. Treatment with NC16A-BP IgG, but not with non-NC16A-BP IgG, significantly decreased the adhesion strength. We speculate that the differences in clinical severity between NC16A-BP and non-NC16A-BP relate to the degree of COL17 depletion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Imafuku, K., Iwata, H., Kamaguchi, M., Izumi, K., Natsuga, K., Ujiie, H., Nishie, W. and Shimizu, H. (2017), Autoantibodies of non‐inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes. Exp Dermatol, 26: 1171-1174., which has been published in final form at https://doi.org/10.1111/exd.13331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	0906-6705
関連情報	PMID 28266727
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/exd.13331