Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A

Yamamoto, Jun; Minatoya, Machiko; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Matsumura, Toru; Kishi, Reiko

Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A

Yamamoto, Jun; Minatoya, Machiko; Sasaki, Seiko et al.

Chemosphere, 2016, 164, 25-31

Permalink : https://hdl.handle.net/2115/72085

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/72085
タイトル	Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A
著者	Yamamoto, Jun ; Minatoya, Machiko ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Matsumura, Toru ; Kishi, Reiko
著者名 Yamamoto, Jun
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Matsumura, Toru
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Bisphenol A
	Maternal blood
	Cord blood
	Human exposure
	Pregnant women
	Japan
発行日	2016-12
出版者	Elsevier
収録物名	Chemosphere
巻(号)	164
ページ	25-31
抄録	Bisphenol A (BPA) is endocrine disrupting chemical that have been detected among general population. Exposure levels among pregnant women and their fetus are yet largely unknown among Japanese. We have developed a new method of measuring total BPA in whole blood samples by using isotopic dilution liquid chromatography-tandem mass spectrometry (ID-LC/MS/MS). For eliminating possible contaminations, we have used glass cartridge instead of polypropylene cartridge and successfully reduced background levels. Additionally gap retention technique was applied to improve sensitivity. We also confirmed no external contamination by measuring free BPA in the samples. The limit of quantification (LOQ) was 0.040 ng/ml. With this developed method, we determined total BPA concentrations of 59 maternal blood at delivery and 285 cord blood samples in prospective birth cohort study and investigated factors possibly related to total BPA levels. Total BPA levels ranged from below LOQ to 0.419 ng/ml and for maternal blood and from below LOQ to 0.217 ng/ml for cord blood, respectively. The geometric mean was 0.051 ng/ml for maternal blood and 0.046 ng/ml for cord blood, respectively. Although no correlation was observed between maternal and fetal blood levels of total BPA, our result suggested fetal exposure to BPA. We have found that younger mothers, frequent beef and pork consumption during pregnancy were positively associated with maternal total BPA levels. We confirmed in utero exposure to BPA, which highlights the importance of further studies of investing the effects of fetus BPA exposure on health outcomes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0045-6535
関連情報	PMID 27573212
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.chemosphere.2016.08.001