Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase

Shingu, Yasushige; Yokota, Takashi; Takada, Shingo; Niwano, Haruki; Ooka, Tomonori; Katoh, Hiroki; Tachibana, Tsuyoshi; Kubota, Suguru; Matsui, Yoshiro

Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase

Shingu, Yasushige; Yokota, Takashi; Takada, Shingo et al.

Journal of cardiology, 2018, 71(1), 65-70

Permalink : https://hdl.handle.net/2115/72285

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アクセス権	open access
URI	https://hdl.handle.net/2115/72285
タイトル	Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase
著者	Shingu, Yasushige ; Yokota, Takashi ; Takada, Shingo ; Niwano, Haruki ; Ooka, Tomonori ; Katoh, Hiroki ; Tachibana, Tsuyoshi ; Kubota, Suguru ; Matsui, Yoshiro
e-Rad_Researcher 30617064 著者名 Shingu, Yasushige
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
e-Rad_Researcher 60722329 著者名 Takada, Shingo
著者名 Niwano, Haruki
e-Rad_Researcher 60507573 著者名 Ooka, Tomonori
著者名 Katoh, Hiroki
著者名 Tachibana, Tsuyoshi
e-Rad_Researcher 70455640 著者名 Kubota, Suguru
e-Rad_Researcher 90219379 著者名 Matsui, Yoshiro
言語	英語
キーワード	Postoperative atrial fibrillation
	Fatty acid binding protein
	Cardiac surgery
発行日	2018-01
出版者	Elsevier
収録物名	Journal of cardiology
巻(号)	71(1)
ページ	65-70
抄録	Background: Post-operative atrial fibrillation (POAF) frequently occurs after cardiac surgery. However, the mechanisms of POAF have not been fully elucidated. We aimed to examine whether pre-operative atrial gene expression related to cardiac metabolism is changed in patients with POAF. Methods: Right atrial tissue was obtained during surgery from 38 patients who underwent cardiac surgery from 2013 to 2015. Atrial expression levels were determined by reverse transcription polymerase chain reaction for the following genes: glucose transporter type 4, peroxisome proliferator-activated receptor-α, fatty acid translocase, carnitine palmitoyltransferase 1B, and fatty acid binding protein 3 (FABP3). To investigate fatty acid β-oxidation and tricarboxylic acid cycle capacities in the mitochondria, β-hydroxyacyl CoA dehydrogenase and citrate synthase activity levels were spectrophotometrically determined. Results: POAF within 7 days after surgery was observed in 18 (47%) patients. POAF patients were significantly older, had a larger left atrial diameter, and had reduced expression of FABP3, a fatty acids transport gene in the cytosol, compared to those in the non-POAF group. Reduced FABP3 expression predicted POAF independent of age and atrial size. In contrast, fatty acid β-oxidation enzymatic activity was comparable between the groups. Conclusions: FABP3 gene expression in the atrium was reduced in patients with POAF. These findings suggest a potential link between altered fatty acid transport in the atrium and increased AF onset after cardiac surgery.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0914-5087
関連情報	PMID 28807550
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jjcc.2017.07.003