Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells

Elfeky, Mohamed; Yoneshiro, Takeshi; Okamatsu-Ogura, Yuko; Kimura, Kazuhiro

Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells

Elfeky, Mohamed; Yoneshiro, Takeshi; Okamatsu-Ogura, Yuko et al.

Journal of biochemistry, 2018, 163(2), 143-153

Permalink : https://hdl.handle.net/2115/72449

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/72449
タイトル	Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells
著者	Elfeky, Mohamed ; Yoneshiro, Takeshi ; Okamatsu-Ogura, Yuko ; Kimura, Kazuhiro
著者名 Elfeky, Mohamed
著者名 Yoneshiro, Takeshi
e-Rad_Researcher 90527178 著者名 Okamatsu-Ogura, Yuko
e-Rad_Researcher 30192561 著者名 Kimura, Kazuhiro
言語	英語
キーワード	adiponectin
	high-mobility group protein B1
	inflammation
	macrophages
	toll-like receptor 4
発行日	2018-02
出版者	Oxford University Press
収録物名	Journal of biochemistry
巻(号)	163(2)
ページ	143-153
抄録	High-mobility group protein B1 (HMGB1) is a late inflammatory mediator released from inflammatory cells when stimulated, resulting in exaggerating septic symptoms. We recently demonstrated that full-length adiponectin, a potent anti-inflammatory adipokine, inhibits lipopolysaccharide-induced HMGB1 release. However, the effects of adiponectin on HMGB1-induced exaggerating signals currently remain unknown. This study aimed to investigate the effects of adiponectin on the pro-inflammatory function of HMGB1 in RAW264 macrophage cells. The treatment of RAW264 cells with HMGB1 significantly up-regulated the mRNA expression of tumour necrosis factor-alpha, interleukin-1 beta and C-X-C motif chemokine 10. HMGB1-induced cytokine expression was markedly suppressed by a toll-like receptor 4 (TLR4) antagonist and slightly suppressed by an antagonist of the receptor for advanced glycation end products. A prior treatment with full-length or globular adiponectin dose-dependently suppressed all types of HMGB1-induced cytokine expression, and this suppression was abolished by compound C, an AMPK inhibitor, but not by the haem oxygenase (HO)-1 inhibitor, zinc protoporphyrin IX. Both forms of adiponectin also reduced the mRNA expression of TLR4. These results suggest that full-length and globular adiponectin suppress HMGB1-induced cytokine expression through an AMPK-mediated HO-1-independent pathway.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in The journal of biochemistry following peer review. The version of record Volume 163, Issue 2, Pages 143-153, 2018 is available online at: https://doi.org/10.1093/jb/mvx069.
PISSN	0021-924X
関連情報	PMID 29048484
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/jb/mvx069