Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size : The Hokkaido study on environment and children's health

Minatoya, Machiko; Araki, Atsuko; Miyashita, Chihiro; Sasaki, Seiko; Goto, Yuko; Nakajima, Tamie; Kishi, Reiko

Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size : The Hokkaido study on environment and children's health

Minatoya, Machiko; Araki, Atsuko; Miyashita, Chihiro et al.

Science of The Total Environment, 2017, 579, 606-611

Permalink : https://hdl.handle.net/2115/72467

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アクセス権	open access
URI	https://hdl.handle.net/2115/72467
タイトル	Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size : The Hokkaido study on environment and children's health
著者	Minatoya, Machiko ; Araki, Atsuko ; Miyashita, Chihiro ; Sasaki, Seiko ; Goto, Yuko ; Nakajima, Tamie ; Kishi, Reiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Goto, Yuko
著者名 Nakajima, Tamie
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	phthalate
	birth weight
	ponderal index
	adiponectin
	leptin
発行日	2017-02-01
出版者	Elsevier
収録物名	Science of The Total Environment
巻(号)	579
ページ	606-611
抄録	Di-2-ethylhexyl phthalate (DEHP) is one of the most widely used phthalates. Metabolites of DEHP are detectable in majority of the population. Findings on adverse health outcomes, particularly birth weight in association with prenatal exposure to DEHP remain equivocal. Besides, there is insufficient evidence to address influence on metabolic function from epidemiological studies. Thus, our objective was to investigate cord blood adipokine levels and birth size in association with prenatal DEHP exposure in prospective birth cohort study. Mono-2-methylhexyl phthalate (MEHP), primary metabolite of DEHP was determined as exposure by using maternal blood sample of 3rd trimester. Leptin and adiponectin levels in cord blood were measured as markers of metabolic function. Birth weight and length were obtained from birth record. Association between maternal MEHP levels and cord blood adiponectin and leptin levels, birth weight and ponderal index (PI) were examined for 167 mother-child pairs who had both MEHP and cord blood adipokine measurements. The median MEHP level was 8.81 ng/ml and the detection rate was 100%. There was no sex difference in MEHP levels. Both leptin and adiponectin levels were higher in girls than in boys. MEHP level was positively associated with adiponectin level among boys and was negatively associated with leptin level among girls. MEHP level were negatively associated with PI only in girls and this could be due to decreased leptin level. This study suggested that prenatal DEHP exposure may be associated with cord blood adipokine and birth size. The influence potentially be sex-specific and could be more significant in girls.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報	PMID 27863867
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2016.11.051