Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study : a prospective birth cohort

Kobayashi, Sumitaka; Sata, Fumihiro; Hanaoka, Tomoyuki; Braimoh, Titilola Serifat; Ito, Kumiko; Tamura, Naomi; Araki, Atsuko; Itoh, Sachiko; Miyashita, Chihiro; Kishi, Reiko

Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study : a prospective birth cohort

Kobayashi, Sumitaka; Sata, Fumihiro; Hanaoka, Tomoyuki et al.

BMJ Open, 2019, 9(2), e023200

Permalink : https://hdl.handle.net/2115/72499

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アクセス権	open access
URI	https://hdl.handle.net/2115/72499
タイトル	Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study : a prospective birth cohort
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Hanaoka, Tomoyuki ; Braimoh, Titilola Serifat ; Ito, Kumiko ; Tamura, Naomi ; Araki, Atsuko ; Itoh, Sachiko ; Miyashita, Chihiro ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
著者名 Hanaoka, Tomoyuki
著者名 Braimoh, Titilola Serifat
著者名 Ito, Kumiko
e-Rad_Researcher 80836164 著者名 Tamura, Naomi
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
発行日	2019-02
出版者	BMJ Publishing Group
収録物名	BMJ Open
巻(号)	9(2)
ページ	e023200
抄録	Objectives: To investigate the association between plasma cotinine level measured at the 8th gestational month and the delivery of small-for-gestational-age (SGA) infants, using a highly sensitive ELISA method. Design: Prospective birth cohort study from The Hokkaido Study on Environment and Children's Health. Setting: Hokkaido, Japan. Participants: Our sample included 15 198 mother-infant pairs enrolled in 2003-2012. Main outcome measures: SGA, defined as a gestational age-specific weight Z-score below -2. Results: The number of SGA infants was 192 (1.3%). The cotinine cut-off level that differentiated SGA infants from other infants was 3.03 ng/mL for both the total population and the full-term births subgroup (sensitivity 0.307; positive predictive value 2.3%). Compared with infants of mothers with a plasma cotinine level of <3.03 ng/mL, infants of mothers with a plasma cotinine level of ≥3.03 ng/mL showed an increased OR for SGA in the total population and the full-term infant group (2.02(95% CI 1.45 to 2.83) and 2.44(95% CI 1.73 to 3.44), respectively). Conclusion: A plasma cotinine level of ≥3.03 ng/mL, which included both passive and active smokers, was associated with an increased risk of SGA. This finding is of important relevance when educating pregnant women about avoiding prenatal passive and active smoking due to the adverse effects on their infants, even those born at full-term.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	2044-6055
関連情報	PMID 30782875
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1136/bmjopen-2018-023200