Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212) : Dose-finding phase

Homma, Akihiro; Onimaru, Rikiya; Matsuura, Kazuto et al.

Head & neck, 2018, 40(3), 475-484

Permalink : https://hdl.handle.net/2115/72733

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アクセス権
open access
URI
https://hdl.handle.net/2115/72733
タイトル
Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212) : Dose-finding phase
その他のタイトル
A dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (JCOG1212) : dose-finding phase
Intra-arterial CRT for maxillary sinus cancer
著者
Homma, Akihiro ; Onimaru, Rikiya ; Matsuura, Kazuto ; Shinomiya, Hirotaka ; Sakashita, Tomohiro ; Shiga, Kiyoto ; Tachibana, Hiroyuki ; Nakamura, Kenichi ; Mizusawa, Junki ; Kitahara, Hideaki ; Eba, Junko ; Fukuda, Haruhiko ; Fujii, Masato ; Hayashi, Ryuichi
e-Rad_Researcher
30312359
著者名
Homma, Akihiro
e-Rad_Researcher
80374461
著者名
Onimaru, Rikiya
e-Rad_Researcher
70271947
著者名
Matsuura, Kazuto
著者名
Shinomiya, Hirotaka
e-Rad_Researcher
30455654
著者名
Sakashita, Tomohiro
e-Rad_Researcher
10187338
著者名
Shiga, Kiyoto
著者名
Tachibana, Hiroyuki
著者名
Nakamura, Kenichi
著者名
Mizusawa, Junki
著者名
Kitahara, Hideaki
著者名
Eba, Junko
著者名
Fukuda, Haruhiko
e-Rad_Researcher
70129633
著者名
Fujii, Masato
著者名
Hayashi, Ryuichi
言語
英語
キーワード
chemoradiotherapy
cisplatin
intra-arterial
maxillary sinus cancer
squamous cell carcinoma
発行日
2018-03
出版者
John Wiley & Sons
収録物名
Head & neck
巻(号)
40(3)
ページ
475-484
抄録
BACKGROUND: We are currently undertaking a multi-institutional prospective trial of the superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy for patients with T4aN0M0 or T4bN0M0 locally advanced maxillary sinus squamous cell carcinomas (MS-SCC). We herein report the results of the dose-finding phase. METHODS: The dose-finding phase sought to evaluate the incidence of dose-limiting toxicities (DLTs) and determine the recommended number of cycles (RC) of the intra-arterial infusion of cisplatin. In this phase, 100 mg/m2 of cisplatin was administered intra-arterially weekly for 7 weeks with concomitant radiotherapy (70 Gy). RESULTS: All 18 patients received a full dose of radiotherapy. The number of cycles of cisplatin was 7 in 13 patients and 6 in 5 patients. DLT was observed in 5 patients. CONCLUSIONS: These results indicated that this therapy is safe and well-tolerated at 7 cycles of cisplatin, which was determined to be the RC for locally advanced MS-SCC.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is the peer reviewed version of the following article: Homma A, Onimaru R, Matsuura K, et al. Dose-finding and efficacy confirmation trial of the superselective intra‐arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose-finding phase. Head & Neck. 2018;40:475–484, which has been published in final form at https://doi.org/10.1002/hed.25001. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN
1043-3074
関連情報
PMID
29130565
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1002/hed.25001