beta-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line

Darwish, Wageh Sobhy; Ikenaka, Yoshinori; Nakayama, Shouta; Mizukawa, Hazuki; Thompson, Lesa A.; Ishizuka, Mayumi

beta-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line

Darwish, Wageh Sobhy; Ikenaka, Yoshinori; Nakayama, Shouta et al.

Environmental science and pollution research, 2018, 25(7), 6320-6328

Permalink : https://hdl.handle.net/2115/72739

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アクセス権	open access
URI	https://hdl.handle.net/2115/72739
タイトル	beta-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line
著者	Darwish, Wageh Sobhy ; Ikenaka, Yoshinori ; Nakayama, Shouta ; Mizukawa, Hazuki ; Thompson, Lesa A. ; Ishizuka, Mayumi
著者名 Darwish, Wageh Sobhy
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Nakayama, Shouta
e-Rad_Researcher 60612661 著者名 Mizukawa, Hazuki
著者名 Thompson, Lesa A.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Carotenoids
	Retinoids
	B[a]P
	Mutagenicity
	Oxidative stress
	HepG2 cells
	Diet
	Pollution
発行日	2018-03
出版者	Springer
収録物名	Environmental science and pollution research
巻(号)	25(7)
ページ	6320-6328
抄録	Benzo[a]pyrene (B[a]P) is one of the polycyclic aromatic hydrocarbons which is formed due to smoking of foods, incomplete combustion of woods, vehicle exhausts, and cigarettes smokes. B[a]P gets entry into human and animal bodies mainly through their diets. Metabolic activation of B[a]P is required to induce mutagenesis and carcinogenesis in animal and human studies. Carotenoids and retinoids are phytochemicals that if ingested have multiple physiological interferences in the human and animal bodies. In this study, we firstly investigated the protective effects of beta-carotene, beta-apo-8-carotenal, retinol, and retinoic acid against B[a]P-induced mutagenicity and oxidative stress in human HepG2 cells. Secondly, we tested the hypothesis of modulating xenobiotic metabolizing enzymes (XMEs) by carotenoids and retinoids as a possible mechanism of protection by these micronutrients against B[a]P adverse effects. The obtained results declared that beta-carotene and retinol significantly reduced B[a]P-induced mutagenicity and oxidative stress. Tested carotenoids and retinoids reduced B[a]P-induced phase I XMEs and induced B[a]P reduced phase II and III XMEs. Thus, the protective effects of these micronutrients are probably due to their ability of induction of phase II and III enzymes and interference with the induction of phase I enzymes by the promutagen, B[a]P. It is highly recommended to consume foods rich in these micronutrients in the areas of high PAH pollution.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0944-1344
関連情報	PMID 29247416
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11356-017-0977-z