open access

https://hdl.handle.net/2115/73354

Modifying oligoalanine conformation by replacement of amide to ester linkage

英語

β-strand

2018-04

John Wiley & Sons

Chirality

30(4)

396-401

Oligo(lactic acid) is an ester-analogue of short oligoalanine sequence and adopts a rigid left-handed helical structure. In this study, oligo(lactic acid) was incorporated into oligoalanine sequences and their conformations were studied by vibrational circular dichroism and electronic circular dichroism spectroscopy. The results suggested that oligo(lactic acid) moiety in these sequences maintains a left-handed helix and increases the conformational propensity of the oligoalanine moiety to form a left-handed polyproline type II-like helix. The importance of the chirality of oligo(lactic acid) moiety for the oligoalanine conformation was also studied. The results obtained in this study should be useful in developing ester-containing oligopeptides that function better than normal peptides.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Chirality. Volume30, Issue4 April 2018 Pages 396-401 This article also appears in: Special Issue: Proceedings 16th International Conference on Chiroptical Spectroscopy, Rennes France 2017 (Volume 30, 2018) which has been published in final form at https://doi.org/10.1002/chir.22823 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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