Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study

Eshak, Ehab S.; Iso, Hiroyasu; Maruyama, Koutatsu; Muraki, Isao; Tamakoshi, Akiko

Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study

Eshak, Ehab S.; Iso, Hiroyasu; Maruyama, Koutatsu et al.

Clinical nutrition, 2018, 37(2), 667-674

Permalink : https://hdl.handle.net/2115/73415

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アクセス権	open access
URI	https://hdl.handle.net/2115/73415
タイトル	Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study
著者	Eshak, Ehab S. ; Iso, Hiroyasu ; Maruyama, Koutatsu ; Muraki, Isao ; Tamakoshi, Akiko
著者名 Eshak, Ehab S.
e-Rad_Researcher 50223053 著者名 Iso, Hiroyasu
著者名 Maruyama, Koutatsu
著者名 Muraki, Isao
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	Cohort study
	Copper
	Iron
	Japanese
	Type 2 diabetes mellitus
	Zinc
発行日	2018-04
出版者	Elsevier
収録物名	Clinical nutrition
巻(号)	37(2)
ページ	667-674
抄録	Background & aims: Abnormal homeostasis of iron, copper and zinc has been included in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the evidence of associations between dietary intakes of these elements and T2DM is limited. We thought to examine the association between dietary intakes of iron, copper and zinc with risk of T2DM in Japanese population. Methods: A prospective study encompassing 16,160 healthy Japanese men and women aged 40-65 years in whom the associations between dietary intakes of iron, copper and zinc, determined by a validated self-administered food frequency questionnaire, with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by logistic regression model. Results: We ascertained 396 self-reported new cases of diabetes within 5-year period. Dietary intakes of iron (total and nonheme but not heme iron) and copper were positively associated with risk of T2DM; the multivariable OR in the highest versus lowest quartiles of intakes were 1.32 (1.04, 1.70; P-trend = 0.03) and 1.55 (1.13, 2.02; P-trend = 0.003), respectively. These associations were more evident in the high risk group; older, overweight, smokers and those with family history of diabetes. The dietary intake of zinc was inversely associated with risk of T2DM; the multivariable OR was 0.64 (0.54, 1.00; P-trend = 0.003), and such association was evident among younger subjects (age 40-55 years) only. Conclusions: Dietary intakes of iron and copper were associated with a higher risk, while dietary intake of zinc was associated with a reduced risk of T2DM in Japanese population.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0261-5614
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.clnu.2017.02.010