Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis : a prospective observational study in 289 cases with degenerative cervical spine disease

Yamada, Katsuhisa; Suda, Kota; Matsumoto Harmon, Satoko; Komatsu, Miki; Ushiku, Chikara; Takahata, Masahiko; Minami, Akio; Iwasaki, Norimasa

Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis : a prospective observational study in 289 cases with degenerative cervical spine disease

Yamada, Katsuhisa; Suda, Kota; Matsumoto Harmon, Satoko et al.

Spinal cord, 2019, 57(1), 58-64

Permalink : https://hdl.handle.net/2115/73804

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アクセス権	open access
URI	https://hdl.handle.net/2115/73804
タイトル	Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis : a prospective observational study in 289 cases with degenerative cervical spine disease
その他のタイトル	DVT in degenerative cervical spine disease
著者	Yamada, Katsuhisa ; Suda, Kota ; Matsumoto Harmon, Satoko ; Komatsu, Miki ; Ushiku, Chikara ; Takahata, Masahiko ; Minami, Akio ; Iwasaki, Norimasa
著者名 Yamada, Katsuhisa
著者名 Suda, Kota
著者名 Matsumoto Harmon, Satoko
著者名 Komatsu, Miki
著者名 Ushiku, Chikara
e-Rad_Researcher 40374368 著者名 Takahata, Masahiko
e-Rad_Researcher 20133738 著者名 Minami, Akio
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
発行日	2019-01
出版者	Nature research
収録物名	Spinal cord
巻(号)	57(1)
ページ	58-64
抄録	Study design: A prospective observational study. Objectives: To determine the incidence of deep venous thrombosis (DVT) and to evaluate the risk factors for DVT development associated with degenerative cervical spine disease. Setting: Hokkaido Spinal Cord Injury Center, Japan. Methods: Between April 2008 and March 2015, patients with degenerative cervical spine disease, such as compressive myelopathy or radiculopathy, who underwent surgical treatment were prospectively assessed. Leg vein ultrasonography and D-dimer tests were performed preoperatively and at 4 days after surgery. All patients received treatment with intermittent pneumatic compression and elastic stockings for primary DVT prophylaxis. No anticoagulation medications were used for DVT prophylaxis. Results: A total of 289 patients (203 males, 86 females; median age: 67 years (interquartile range, 58-76)) were included. Nine patients (3.1%) exhibited DVT during the perioperative period. All 9 cases were women who had distal DVT. The incidences of preoperative and postoperative DVT were 1.1% and 2.1%, respectively. The univariate analysis showed that statistically significant risk factors for perioperative DVT included female gender (P < 0.01), advanced age (P = 0.04), a low Japanese Orthopaedic Association score (P = 0.03), rapidly progressive myelopathy (P < 0.01), and inability to walk (P = 0.01). The multivariate analysis showed that rapidly progressive myelopathy (P = 0.04) was the most important risk factor. Conclusion: Female gender and rapidly progressive myelopathy are high-risk factors that predict the development of DVT during the perioperative period of cervical spine surgery. This result indicates that screening and treatment for DVT are needed in such high-risk patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1362-4393
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/s41393-018-0213-9