Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T : Comparison with O-15-labeled Water Positron Emission Tomography

Kikuchi, Yasuka; Naya, Masanao; Oyama-Manabe, Noriko; Manabe, Osamu; Sugimori, Hiroyuki; Kudo, Kohsuke; Kato, Fumi; Aikawa, Tadao; Tsutsui, Hiroyuki; Tamaki, Nagara; Shirato, Hiroki

Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T : Comparison with O-15-labeled Water Positron Emission Tomography

Kikuchi, Yasuka; Naya, Masanao; Oyama-Manabe, Noriko et al.

Magnetic resonance in medical sciences, 2019, 18(2), 134-141

Permalink : https://hdl.handle.net/2115/74040

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アクセス権	open access
URI	https://hdl.handle.net/2115/74040
タイトル	Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T : Comparison with O-15-labeled Water Positron Emission Tomography
著者	Kikuchi, Yasuka ; Naya, Masanao ; Oyama-Manabe, Noriko ; Manabe, Osamu ; Sugimori, Hiroyuki ; Kudo, Kohsuke ; Kato, Fumi ; Aikawa, Tadao ; Tsutsui, Hiroyuki ; Tamaki, Nagara ; Shirato, Hiroki
e-Rad_Researcher 80783539 著者名 Kikuchi, Yasuka
e-Rad_Researcher 20455637 著者名 Naya, Masanao
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 40443957 著者名 Manabe, Osamu
e-Rad_Researcher 20711899 著者名 Sugimori, Hiroyuki
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 80399865 著者名 Kato, Fumi
e-Rad_Researcher 20795059 著者名 Aikawa, Tadao
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	coronary artery disease
	coronary flow velocity reserve
	magnetic resonance imaging
	phase contrast
	3 tesla
発行日	2019
出版者	Japanese Society for Magnetic Resonance in Medicine
収録物名	Magnetic resonance in medical sciences
巻(号)	18(2)
ページ	134-141
抄録	Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by O-15-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R-2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 +/- 0.61 vs. 2.77 +/- 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 +/- 0.84 vs. 3.96 +/- 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1347-3182
関連情報	PMID 30047496
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2463/mrms.mp.2018-0003