Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

Yasukawa, Shinichiro; Kano, Satoshi; Hatakeyama, Hiromitsu; Nakamaru, Yuji; Takagi, Dai; Mizumachi, Takatsugu; Suzuki, Masanobu; Suzuki, Takayoshi; Nakazono, Akira; Tanaka, Shinya; Nishihara, Hiroshi; Homma, Akihiro

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

Yasukawa, Shinichiro; Kano, Satoshi; Hatakeyama, Hiromitsu et al.

International journal of clinical oncology, 2018, 23(5), 835-843

Permalink : https://hdl.handle.net/2115/74188

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アクセス権	open access
URI	https://hdl.handle.net/2115/74188
タイトル	Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing
著者	Yasukawa, Shinichiro ; Kano, Satoshi ; Hatakeyama, Hiromitsu ; Nakamaru, Yuji ; Takagi, Dai ; Mizumachi, Takatsugu ; Suzuki, Masanobu ; Suzuki, Takayoshi ; Nakazono, Akira ; Tanaka, Shinya ; Nishihara, Hiroshi ; Homma, Akihiro
著者名 Yasukawa, Shinichiro
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
著者名 Takagi, Dai
e-Rad_Researcher 00507577 著者名 Mizumachi, Takatsugu
著者名 Suzuki, Masanobu
著者名 Suzuki, Takayoshi
著者名 Nakazono, Akira
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 50322805 著者名 Nishihara, Hiroshi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
言語	英語
キーワード	Inverted papilloma
	Malignant transformation
	Squamous cell carcinoma
	Targeted amplicon sequence
	NGS
発行日	2018-10
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	23(5)
ページ	835-843
抄録	Background: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. Methods: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. Results: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Conclusion: Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in International Journal of Clinical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10147-018-1296-1
PISSN	1341-9625
関連情報	PMID 29779136
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-018-1296-1