Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates.

Anindita, Paulina D; Sasaki, Michihito; Gonzalez, Gabriel; Phongphaew, Wallaya; Carr, Michael; Hang'ombe, Bernard M; Mweene, Aaron S; Ito, Kimihito; Orba, Yasuko; Sawa, Hirofumi

Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates.

Anindita, Paulina D; Sasaki, Michihito; Gonzalez, Gabriel et al.

Scientific reports, 2019, 9(1), 5045

Permalink : https://hdl.handle.net/2115/74612

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Table S1	docx	21.6 KB	125	Supplemental Data

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/74612
タイトル	Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates.
著者	Anindita, Paulina D ; Sasaki, Michihito ; Gonzalez, Gabriel ; Phongphaew, Wallaya ; Carr, Michael ; Hang'ombe, Bernard M ; Mweene, Aaron S ; Ito, Kimihito ; Orba, Yasuko ; Sawa, Hirofumi
著者名 Anindita, Paulina D
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
著者名 Gonzalez, Gabriel
著者名 Phongphaew, Wallaya
e-Rad_Researcher 70769588 著者名 Carr, Michael
著者名 Hang'ombe, Bernard M
著者名 Mweene, Aaron S
e-Rad_Researcher 60396314 著者名 Ito, Kimihito
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
言語	英語
発行日	2019-04-08
出版者	Nature Publishing Group
収録物名	Scientific reports
巻(号)	9(1)
ページ	5045
抄録	The Smacoviridae has recently been classified as a family of small circular single-stranded DNA viruses. An increasing number of smacovirus genomes have been identified exclusively in faecal matter of various vertebrate species and from insect body parts. However, the genetic diversity and host range of smacoviruses remains to be fully elucidated. Herein, we report the genetic characterization of eleven circular replication-associated protein (Rep) encoding single-stranded (CRESS) DNA viruses detected in the faeces of Zambian non-human primates. Based on pairwise genome-wide and amino acid identities with reference smacovirus species, ten of the identified CRESS DNA viruses are assigned to the genera Porprismacovirus and Huchismacovirus of the family Smacoviridae, which bidirectionally encode two major open reading frames (ORFs): Rep and capsid protein (CP) characteristic of a type IV genome organization. The remaining unclassified CRESS DNA virus was related to smacoviruses but possessed a genome harbouring a unidirectionally oriented CP and Rep, assigned as a type V genome organization. Moreover, phylogenetic and recombination analyses provided evidence for recombination events encompassing the 3'-end of the Rep ORF in the unclassified CRESS DNA virus. Our findings increase the knowledge of the known genetic diversity of smacoviruses and highlight African non-human primates as carrier animals.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
EISSN	2045-2322
関連情報	PMID 30962460
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-019-41358-z