Adalimumab in Active and Inactive, Non-Infectious Uveitis : Global Results from the VISUAL I and VISUAL II Trials

Goto, Hiroshi; Zako, Masahiro; Namba, Kenichi; Hashida, Noriyasu; Kaburaki, Toshikatsu; Miyazaki, Masanori; Sonoda, Koh-Hei; Abe, Toshiaki; Mizuki, Nobuhisa; Kamoi, Koju; Brezin, Antoine P.; Dick, Andrew D.; Jaffe, Glenn J.; Nguyen, Quan Dong; Inomata, Noritaka; Kwatra, Nisha V.; Camez, Anne; Song, Alexandra P.; Kron, Martina; Tari, Samir; Ohno, Shigeaki

Adalimumab in Active and Inactive, Non-Infectious Uveitis : Global Results from the VISUAL I and VISUAL II Trials

Goto, Hiroshi; Zako, Masahiro; Namba, Kenichi et al.

Ocular immunology and inflammation, 2019, 27(1), 40-50

Permalink : https://hdl.handle.net/2115/74631

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アクセス権	open access
URI	https://hdl.handle.net/2115/74631
タイトル	Adalimumab in Active and Inactive, Non-Infectious Uveitis : Global Results from the VISUAL I and VISUAL II Trials
著者	Goto, Hiroshi ; Zako, Masahiro ; Namba, Kenichi ; Hashida, Noriyasu ; Kaburaki, Toshikatsu ; Miyazaki, Masanori ; Sonoda, Koh-Hei ; Abe, Toshiaki ; Mizuki, Nobuhisa ; Kamoi, Koju ; Brezin, Antoine P. ; Dick, Andrew D. ; Jaffe, Glenn J. ; Nguyen, Quan Dong ; Inomata, Noritaka ; Kwatra, Nisha V. ; Camez, Anne ; Song, Alexandra P. ; Kron, Martina ; Tari, Samir ; Ohno, Shigeaki
e-Rad_Researcher 10201500 著者名 Goto, Hiroshi
e-Rad_Researcher 80298596 著者名 Zako, Masahiro
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 30456959 著者名 Hashida, Noriyasu
e-Rad_Researcher 00280941 著者名 Kaburaki, Toshikatsu
e-Rad_Researcher 40380638 著者名 Miyazaki, Masanori
e-Rad_Researcher 10294943 著者名 Sonoda, Koh-Hei
e-Rad_Researcher 90191858 著者名 Abe, Toshiaki
e-Rad_Researcher 90336579 著者名 Mizuki, Nobuhisa
e-Rad_Researcher 40451942 著者名 Kamoi, Koju
著者名 Brezin, Antoine P.
著者名 Dick, Andrew D.
著者名 Jaffe, Glenn J.
著者名 Nguyen, Quan Dong
著者名 Inomata, Noritaka
著者名 Kwatra, Nisha V.
著者名 Camez, Anne
著者名 Song, Alexandra P.
著者名 Kron, Martina
著者名 Tari, Samir
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
キーワード	Active uveitis
	adalimumab
	inactive uveitis
	non-infectious uveitis
	ocular inflammation
発行日	2019-01-02
出版者	Taylor & Francis
収録物名	Ocular immunology and inflammation
巻(号)	27(1)
ページ	40-50
抄録	Purpose: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis. Methods: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported. The primary endpoint was time to treatment failure (TF). Results: In the integrated studies, TF risk was significantly reduced (hazard ratio [95% CI]) with adalimumab versus placebo (VISUAL I: HR = 0.56 [0.40-0.76], p < 0.001; VISUAL II: HR = 0.52 [0.37-0.74], p < 0.001). In Japan substudies, no consistent trends were observed between groups (VISUAL I: HR = 1.20 [0.41-3.54]; VISUAL II: HR = 0.45 [0.20-1.03]). Adverse event rates were similar between treatment groups in both studies (854 to 1063 events/100 participant-years). Conclusions: Adalimumab lowered time to TF versus placebo in the integrated population; no consistent trends were observed in Japan substudies. Safety results were consistent between studies.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 3.0 Unported
PISSN	0927-3948
関連情報	PMID 30015528
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1080/09273948.2018.1491605