Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size : The Hokkaido Study on environment and children's health

Minatoya, Machiko; Itoh, Sachiko; Miyashita, Chihiro; Araki, Atsuko; Sasaki, Seiko; Miura, Ryu; Goudarzi, Houman; Iwasaki, Yusuke; Kishi, Reiko

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size : The Hokkaido Study on environment and children's health

Minatoya, Machiko; Itoh, Sachiko; Miyashita, Chihiro et al.

Environmental research, 2017, 156, 175-182

Permalink : https://hdl.handle.net/2115/74823

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/74823
タイトル	Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size : The Hokkaido Study on environment and children's health
著者	Minatoya, Machiko ; Itoh, Sachiko ; Miyashita, Chihiro ; Araki, Atsuko ; Sasaki, Seiko ; Miura, Ryu ; Goudarzi, Houman ; Iwasaki, Yusuke ; Kishi, Reiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Miura, Ryu
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 10409360 著者名 Iwasaki, Yusuke
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Adiponectin
	Leptin
	PFOS
	PFOA
	Birth cohort
発行日	2017-07
出版者	Elsevier
収録物名	Environmental research
巻(号)	156
ページ	175-182
抄録	Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4 ng/mL, respectively. The median total adiponectin and leptin levels were 19.4 μg/mL and 6.2 ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0013-9351
関連情報	PMID 28349882
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envres.2017.03.033