Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment

Asano, Toshimichi; Hirano, Satoshi; Nakamura, Toru; Okamura, Keisuke; Tsuchikawa, Takahiro; Noji, Takehiro; Nakanishi, Yoshitsugu; Tanaka, Kimitaka; Shichinohe, Toshiaki

Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment

Asano, Toshimichi; Hirano, Satoshi; Nakamura, Toru et al.

Journal of hepato-biliary-pancreatic sciences, 2018, 25(7), 342-350

Permalink : https://hdl.handle.net/2115/74831

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アクセス権	open access
URI	https://hdl.handle.net/2115/74831
タイトル	Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment
著者	Asano, Toshimichi ; Hirano, Satoshi ; Nakamura, Toru ; Okamura, Keisuke ; Tsuchikawa, Takahiro ; Noji, Takehiro ; Nakanishi, Yoshitsugu ; Tanaka, Kimitaka ; Shichinohe, Toshiaki
e-Rad_Researcher 10756688 著者名 Asano, Toshimichi
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
e-Rad_Researcher 70645796 著者名 Nakamura, Toru
e-Rad_Researcher 90724401 著者名 Okamura, Keisuke
e-Rad_Researcher 50507572 著者名 Tsuchikawa, Takahiro
e-Rad_Researcher 10739296 著者名 Noji, Takehiro
e-Rad_Researcher 40447058 著者名 Nakanishi, Yoshitsugu
e-Rad_Researcher 10758642 著者名 Tanaka, Kimitaka
e-Rad_Researcher 70374353 著者名 Shichinohe, Toshiaki
言語	英語
キーワード	Conversion surgery
	Multidisciplinary treatment
	Prognosis
	Survival analysis
	Unresectable pancreatic cancer
発行日	2018-07
出版者	John Wiley & Sons
収録物名	Journal of hepato-biliary-pancreatic sciences
巻(号)	25(7)
ページ	342-350
抄録	Background: Conversion surgery (CS) is expected as a new therapeutic strategy for patients with unresectable pancreatic cancer (UR-PC). We analyzed outcomes of CS for patients with UR-PC and evaluated the survival benefit of CS. Methods: Thirty-four patients diagnosed with UR-PC according to the National Comprehensive Cancer Network guideline underwent CS in our hospital. Resectability was considered by multimodal images in patients who underwent nonsurgical treatment (NST) for more than 6 months. CS was performed only in patients who were judged to be able to undergo R0 resection. Results: Twenty-six patients had locally advanced PC, and eight had distant metastases. The median duration of NST was 9 (range 5-44) months. R0 resection was achieved in 30 patients (88.2%). Six patients (17.6%) showed Evans grade ≥III. Three- and 5-year overall survival (OS) rates from initial treatment were 74% and 56.9%, respectively, with median survival time (MST) of 5.3 years. The actual 5-year OS rate in 19 patients was 47.4% with an MST of 4.0 years. Patients with Evans grade ≥III had a better prognosis than those with Evans grade <III (P = 0.0092, log-rank test). Conclusions: Conversion surgery might have survival benefits to patients with UR-PC who responded favorably to NST.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Asano, T., Hirano, S., Nakamura, T., Okamura, K., Tsuchikawa, T., Noji, T., Nakanishi, Y., Tanaka, K. and Shichinohe, T. (2018), Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment. J Hepatobiliary Pancreat Sci, 25: 342-350., which has been published in final form at https://doi.org/10.1002/jhbp.565. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN	1868-6974
関連情報	PMID 29797499
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/jhbp.565