Genetic diversity of MHC class II DRB alleles in the continental and Japanese populations of the sable Martes zibellina (Mustelidae, Carnivora, Mammalia)

Nishita, Yoshinori; Abramov, Alexei V; Murakami, Takahiro; Masuda, Ryuichi

Genetic diversity of MHC class II DRB alleles in the continental and Japanese populations of the sable Martes zibellina (Mustelidae, Carnivora, Mammalia)

Nishita, Yoshinori; Abramov, Alexei V; Murakami, Takahiro et al.

Mammal Research, 2018, 63(3), 369-378

Permalink : https://hdl.handle.net/2115/74848

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アクセス権	open access
URI	https://hdl.handle.net/2115/74848
タイトル	Genetic diversity of MHC class II DRB alleles in the continental and Japanese populations of the sable Martes zibellina (Mustelidae, Carnivora, Mammalia)
著者	Nishita, Yoshinori ; Abramov, Alexei V ; Murakami, Takahiro ; Masuda, Ryuichi
e-Rad_Researcher 10281841 著者名 Nishita, Yoshinori
著者名 Abramov, Alexei V
著者名 Murakami, Takahiro
e-Rad_Researcher 80192748 著者名 Masuda, Ryuichi
言語	英語
キーワード	Balancing selection
	DRB gene
	Major histocompatibility complex
	Molecular evolution
	Trans-species polymorphism
	Martes zibellina
発行日	2018-07
出版者	Springer
収録物名	Mammal Research
巻(号)	63(3)
ページ	369-378
抄録	The sable (Martes zibellina) is a medium-sized mustelid inhabiting forest environments in Siberia, northern China, the Korean Peninsula, and Hokkaido Island, Japan. To further understand the molecular evolution of the major histocompatibility complex (MHC), we sequenced part of exon 2 in MHC class II DRB genes, including codons encoding the antigen binding site, from 33 individuals from continental Eurasia and Japan. We identified 16 MHC class II DRB alleles (Mazi-DRBs), some of which were geographically restricted and others broadly distributed, and eight putative pseudogenes. A single-breakpoint recombination analysis detected a recombination site in the middle of exon 2. A mixed effects model of evolution analysis identified five amino acid sites presumably under positive selection. These sites were all located in the region 3' to the recombination site, suggesting that positive selection and recombination could be committed to the diversity of the M. zibellina DRB gene. In a Bayesian phylogenetic free, all Mazi-DRBs and the presumed pseudogenes grouped within a Mustelidae clade. The Mazi-DRBs showed trans-species polymorphism, with some alleles most closely related to alleles from other mustelid species. This result suggests that the sable DRBs have evolved under long-lasting balancing selection.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	2199-2401
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s13364-018-0366-0