Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report

Matsuoka, Masatake; Onodera, Tomohiro; Majima, Tokifumi et al.

BMC musculoskeletal disorders, 2019, 20, 287

Permalink : https://hdl.handle.net/2115/75005

このアイテムのアクセス数:687件（2026-10-15 05:17 集計）

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https://doi.org/10.1186/s12891-019-2665-2     17

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/75005
タイトル
Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report
著者
Matsuoka, Masatake ; Onodera, Tomohiro ; Majima, Tokifumi ; Iwasaki, Koji ; Takahashi, Daisuke ; Kondo, Eiji ; Iwasaki, Norimasa
e-Rad_Researcher
70816066
著者名
Matsuoka, Masatake
e-Rad_Researcher
70547174
著者名
Onodera, Tomohiro
e-Rad_Researcher
30241334
著者名
Majima, Tokifumi
e-Rad_Researcher
40771895
著者名
Iwasaki, Koji
e-Rad_Researcher
90528845
著者名
Takahashi, Daisuke
e-Rad_Researcher
60374724
著者名
Kondo, Eiji
e-Rad_Researcher
30322803
著者名
Iwasaki, Norimasa
言語
英語
キーワード
Retinoid therapy
Premature epiphyseal closure
13-cis-retinoic acid
Osteopenia
発行日
2019-06-15
出版者
BioMed Central
収録物名
BMC musculoskeletal disorders
巻(号)
20
ページ
287
抄録
BackgroundA vitamin A derivative, 13-cis-retinoic acid (isotretinoin), has been administered to treat several types of pediatric cancer and has improved survival rates in patients despite being known to induce premature epiphyseal closure. As the number of patients treated by 13-cis-retinoic acid increases, demands for salvage treatment after systemic retinoid therapy are emerging. However, few studies have described the surgical treatment of this disease.Case presentationWe report a case with bilateral varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin for neuroblastoma. The patient was successfully treated with correction osteotomy using a Taylor spatial frame in the right knee joint and femoral closed wedge osteotomy using a locking plate in left knee joint. Histopathological examination of the growth plate showed polar irregularity of chondrocytes and decreased cartilage matrix without apoptosis. In contrast, arthroscopic findings showed an intact joint surface. No recurrence of varus deformity was evident on follow-up at 1year.ConclusionsTo the best of our knowledge, this represents the first report of correction osteotomy for varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1471-2474
EISSN
1471-2474
NCID
AA12035278
関連情報
PMID
31202274
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s12891-019-2665-2