Regulatory T cells in autoimmune skin diseases

Ujiie, Hideyuki

Experimental dermatology, 2019, 28(6), 642-646

Permalink : https://hdl.handle.net/2115/75007

このアイテムのアクセス数:588件（2026-10-09 02:21 集計）

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1111/exd.13535			106

アクセス権	open access
URI	https://hdl.handle.net/2115/75007
タイトル	Regulatory T cells in autoimmune skin diseases
著者	e-Rad_Researcher 60374435 著者名 Ujiie, Hideyuki
言語	英語
キーワード	alopecia areata
	pemphigoid
	pemphigus
	systemic sclerosis
	vitiligo
発行日	2019-06
出版者	John Wiley & Sons
収録物名	Experimental dermatology
巻(号)	28(6)
ページ	642-646
抄録	CD4(+)Foxp3(+) regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs and the differences in genetic background regarding Tregs in autoimmune skin disorders. Recent studies have extended our knowledge of certain properties of Tregs, especially skin-resident Tregs. In addition, some novel therapies have been performed by modulating the number and the function of Tregs. This review focuses on the role of Tregs in some autoimmune skin disorders, including alopecia areata, vitiligo, pemphigoid and pemphigus, and systemic sclerosis, and discusses questions that remain to be addressed.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0906-6705
関連情報	PMID 29575350
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/exd.13535