open access

https://hdl.handle.net/2115/75108

Contrast improvement in indocyanine green fluorescence sensing in thick tissue using a time-gating method

英語

2019-03-01

Optical Society of America

Biomedical Optics Express

10(3)

1234-1249

Indocyanine green-based fluorescence imaging techniques are very powerful in clinical applications, but the imaging is restricted to the signal from the near-surface region of tissue. Here, we focus on the method to discriminate the fluorescence signal from the background using a time-domain gating technique. The contrast of the fluorescence image from a fluorescence object at more than 1 cm depth in a meat phantom could be enhanced about 4-5 times relative to the continuous wave method if the time-gate range was properly selected. Further, a Monte Carlo simulation with a simple background model indicates that a shorter source and detector distance is more effective to improve the contrast. The simple time-gating method will enable a highly sensitive fluorescence detection in thick tissue. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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© 2019 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.

2156-7085