Intestinal α-Glucosidase Inhibitors in Achillea millefolium

Noda, Kota; Kato, Eisuke; Kawabata, Jun

Intestinal α-Glucosidase Inhibitors in Achillea millefolium

Noda, Kota; Kato, Eisuke; Kawabata, Jun

Natural Product Communications, 2017, 12(8), 1259-1261

Permalink : https://hdl.handle.net/2115/75147

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アクセス権	open access
URI	https://hdl.handle.net/2115/75147
タイトル	Intestinal α-Glucosidase Inhibitors in Achillea millefolium
著者	Noda, Kota ; Kato, Eisuke ; Kawabata, Jun
著者名 Noda, Kota
e-Rad_Researcher 40466446 著者名 Kato, Eisuke
e-Rad_Researcher 60142197 著者名 Kawabata, Jun
言語	英語
キーワード	Diabetes
	Intestinal α-glucosidase
	Maltase
	Glucosidase inhibitor
	Caffeoylquinic acid
発行日	2017-08-01
出版者	SAGE
収録物名	Natural Product Communications
巻(号)	12(8)
ページ	1259-1261
抄録	Achillea millefolium is a plant used as a component of anti-diabetic preparation but the bioactive compounds responsible for its use are not known. Inhibition of intestinal α-glucosidase is a preferable effect for prevention and treatment of diabetes, and A. millefolium extract showed inhibitory activity against the enzyme. Activity-guided separation of the extract gave four mono- or di-caffeoylquinic acids as the isolate. Quantitation of these four caffeoylquinic acids and the activity of the isolates suggested that these are the major contributor for the α-glucosidase inhibitory activity in the extract. However also, the presence of unidentified, minor, but potent α-glucosidase inhibitor in the isolate was also suggested.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Kota Noda, Eisuke Kato, Jun Kawabata, Intestinal α-Glucosidase Inhibitors in Achillea millefolium, Natural Product Communications (Vol12 No.8) pp. 1259-1261. Copyright © 2017(SAGE). DOI:10.1177/1934578X1701200828.
PISSN	1934-578X
EISSN	1555-9475
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1177/1934578X1701200828