MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

Xu, Daozhi; Dong, Peixin; Xiong, Ying et al.

Cancers, 2019, 11(8), 1130

Permalink : https://hdl.handle.net/2115/75182

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Final published miR-361 cancers-11-01130 pdf 1.41 MB 507

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/75182
タイトル
MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation
著者
Xu, Daozhi ; Dong, Peixin ; Xiong, Ying ; Yue, Junming ; Ihira, Kei ; Konno, Yosuke ; Kobayashi, Noriko ; Todo, Yukiharu ; Watari, Hidemichi
著者名
Xu, Daozhi
e-Rad_Researcher
50602504
著者名
Dong, Peixin
著者名
Xiong, Ying
著者名
Yue, Junming
e-Rad_Researcher
50813820
著者名
Ihira, Kei
e-Rad_Researcher
10572703
著者名
Konno, Yosuke
著者名
Kobayashi, Noriko
e-Rad_Researcher
90374389
著者名
Todo, Yukiharu
e-Rad_Researcher
10344508
著者名
Watari, Hidemichi
言語
英語
キーワード
microRNA-361
EMT
angiogenesis
tumor microenvironment
cancer diagnosis
cancer treatment
発行日
2019-08
出版者
MDPI
収録物名
Cancers
巻(号)
11(8)
ページ
1130
抄録
MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2072-6694
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/cancers11081130