Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features

Leela-Arporn, Rommaneeya; Ohta, Hiroshi; Tamura, Masahiro; Nagata, Noriyuki; Sasaoka, Kazuyoshi; Dermlim, Angkhana; Nisa, Khoirun; Morishita, Keitaro; Sasaki, Noboru; Nakamura, Kensuke; Takagi, Satoshi; Hosoya, Kenji; Takiguchi, Mitsuyoshi

Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features

Leela-Arporn, Rommaneeya; Ohta, Hiroshi; Tamura, Masahiro et al.

Journal of veterinary medical science, 2019, 81(5), 723-729

Permalink : https://hdl.handle.net/2115/75187

このアイテムのアクセス数:770件（2026-08-09 11:42 集計）

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https://doi.org/10.1292/jvms.18-0673			13

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アクセス権	open access
URI	https://hdl.handle.net/2115/75187
タイトル	Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features
著者	Leela-Arporn, Rommaneeya ; Ohta, Hiroshi ; Tamura, Masahiro ; Nagata, Noriyuki ; Sasaoka, Kazuyoshi ; Dermlim, Angkhana ; Nisa, Khoirun ; Morishita, Keitaro ; Sasaki, Noboru ; Nakamura, Kensuke ; Takagi, Satoshi ; Hosoya, Kenji ; Takiguchi, Mitsuyoshi
著者名 Leela-Arporn, Rommaneeya
著者名 Ohta, Hiroshi
著者名 Tamura, Masahiro
著者名 Nagata, Noriyuki
著者名 Sasaoka, Kazuyoshi
著者名 Dermlim, Angkhana
著者名 Nisa, Khoirun
著者名 Morishita, Keitaro
著者名 Sasaki, Noboru
著者名 Nakamura, Kensuke
著者名 Takagi, Satoshi
著者名 Hosoya, Kenji
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	canine
	classification
	liver nodule
	malignancy
	ultrasonography
発行日	2019-05
出版者	公益社団法人日本獣医学会
出版者	The Japanese Society of Veterinary Science
収録物名	Journal of veterinary medical science
巻(号)	81(5)
ページ	723-729
抄録	A definitive diagnosis of focal liver lesions (FLLs) requires invasive procedures for histopathologic examination. Thus, a simpler noninvasive diagnostic method, such as conventional ultrasonography combined with clinical data, is needed for the prediction of liver malignancy. The objective of this study was to examine the diagnostic accuracy of clinical data and ultrasonographic (US) features to differentiate benign and malignant liver lesions. Medical records and US images from dogs with FLLs that underwent abdominal US and histopathologic examinations following surgery or liver biopsy were retrospectively reviewed. Clinical data, including signalment, clinical signs and laboratory findings, and the US features of liver lesions that could act as predictive factors were assessed using univariate and multivariate analyses to evaluate the associations between predictive factors and liver malignancy. Based on the histopathologic results, 55 dogs with malignant lesions and 28 dogs with benign lesions were included in the study. The results of univariate analysis showed that several US features and platelet count were significantly associated with liver malignancy. Multivariate analysis revealed that the platelet count (thrombocytosis; odds ratio [OR]: 4.13, 95% confidence intervals [CI]: 1.81-9.41), lesion size (4.1 cm or greater; OR: 23.83, 95% CI: 3.74-151.95) and echotexture of FLLs (heterogenous; OR: 8.44; 95% CI: 1.37-51.91) were independent predictors for differentiating benign and malignant liver lesions, suggesting that a combination of clinical data and US findings of FLLs could predict liver malignancy in dogs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0916-7250
関連情報	PMID 30956270
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.18-0673